Visualization of neural tissue water compartments using biexponential diffusion tensor MRI

B. A. Inglis, E. L. Bossart, D. L. Buckley, E. D. Wirth, T. H. Mareci

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102 Scopus citations

Abstract

The apparent diffusion tensor (ADT) imaging method was extended to account for multiple diffusion components. A biexponential ADT imaging experiment was used to obtain separate images of rapidly and slowly diffusing water fractions in excised rat spinal cord. The fast and slow component tensors were compared and found to exhibit similar gross features, such as fractional anisotropy, in both white and gray matter. However, there were also some important differences, which are consistent with the different structures occupying intracellular and extracellular spaces. Evidence supporting the assignment of the two tensor components to extracellular and intracellular water fractions is provided by an NMR spectroscopic investigation of homogeneous samples of brain tissue.

Original languageEnglish (US)
Pages (from-to)580-587
Number of pages8
JournalMagnetic Resonance in Medicine
Volume45
Issue number4
DOIs
StatePublished - Apr 12 2001

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Keywords

  • Biexponential
  • Diffusion
  • Spinal cord
  • Tensor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Inglis, B. A., Bossart, E. L., Buckley, D. L., Wirth, E. D., & Mareci, T. H. (2001). Visualization of neural tissue water compartments using biexponential diffusion tensor MRI. Magnetic Resonance in Medicine, 45(4), 580-587. https://doi.org/10.1002/mrm.1079