Visualization of Focal Thinning of the Ganglion Cell-Inner Plexiform Layer in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Yi Shao, Hong Jiang, Yantao Wei, Yingying Shi, Ce Shi, Clinton B. Wright, Xiaoyan Sun, Elizabeth A. Vanner, Anny D. Rodriguez, Byron L Lam, Tatjana Rundek, Bernard Baumel, Giovana Rosa Gameiro, Chuanhui Dong, Jianhua Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND: A detailed analysis of the tomographic thickness of intraretinal layers may provide more information on neurodegeneration in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). OBJECTIVE: The goal was to analyze tomographic thickness patterns of intraretinal layers in patients with AD andMCI. METHOD: Forty-nine patients (25 AD and 24 MCI) and 21 cognitively normal (CN) controls were imaged using ultra-high-resolution optical coherence tomography to obtain volumetric data centered on the fovea. The segmented intraretinal layers were retinal nerve fiber layer (RNFL), ganglion cell- inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL), and retinal photoreceptor (PR), in addition to the total retinal thickness(TRT). RESULTS: The thickness differences were negative (thinning) mainly in TRT, RNFL, and GCIPL in both AD and MCI groups in comparison to CN, while the thickness differences were positive (thickening) mainly in ONL and PR in AD. GCIPL of AD and MCI was thinner in superior, nasal superior, and temporal superior quadrants, compared to CN (p < 0.05). GCIPL of the inner superior, inner nasal superior, inner temporal superior, and outer nasal superior sectors was significantly thinner in AD than CN (p < 0.05). GCIPL of the outer superior, inner temporal superior, outer nasal, and temporal superior sectors was significantly thinner in MCI than CN (p < 0.05). CONCLUSION: Focal thinning of the GCIPL was visualized and quantified by detailed partitions in AD and MCI, which provides specific information about neurodegeneration in MCI and AD.

Original languageEnglish (US)
Pages (from-to)1261-1273
Number of pages13
JournalJournal of Alzheimer's disease : JAD
Volume64
Issue number4
DOIs
StatePublished - Jan 1 2018

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Ganglia
Alzheimer Disease
Nose
Nerve Fibers
Cognitive Dysfunction
Vertebrate Photoreceptor Cells
Optical Coherence Tomography

Keywords

  • Alzheimer’s disease
  • ETDRS partition
  • ganglion-inner plexiform layer
  • hemispheric partition
  • mild cognitive impairment
  • retinal thickness mapping
  • ultrahigh-resolution OCT
  • Zeiss elliptical partition

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Visualization of Focal Thinning of the Ganglion Cell-Inner Plexiform Layer in Patients with Mild Cognitive Impairment and Alzheimer's Disease. / Shao, Yi; Jiang, Hong; Wei, Yantao; Shi, Yingying; Shi, Ce; Wright, Clinton B.; Sun, Xiaoyan; Vanner, Elizabeth A.; Rodriguez, Anny D.; Lam, Byron L; Rundek, Tatjana; Baumel, Bernard; Gameiro, Giovana Rosa; Dong, Chuanhui; Wang, Jianhua.

In: Journal of Alzheimer's disease : JAD, Vol. 64, No. 4, 01.01.2018, p. 1261-1273.

Research output: Contribution to journalArticle

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title = "Visualization of Focal Thinning of the Ganglion Cell-Inner Plexiform Layer in Patients with Mild Cognitive Impairment and Alzheimer's Disease",
abstract = "BACKGROUND: A detailed analysis of the tomographic thickness of intraretinal layers may provide more information on neurodegeneration in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). OBJECTIVE: The goal was to analyze tomographic thickness patterns of intraretinal layers in patients with AD andMCI. METHOD: Forty-nine patients (25 AD and 24 MCI) and 21 cognitively normal (CN) controls were imaged using ultra-high-resolution optical coherence tomography to obtain volumetric data centered on the fovea. The segmented intraretinal layers were retinal nerve fiber layer (RNFL), ganglion cell- inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL), and retinal photoreceptor (PR), in addition to the total retinal thickness(TRT). RESULTS: The thickness differences were negative (thinning) mainly in TRT, RNFL, and GCIPL in both AD and MCI groups in comparison to CN, while the thickness differences were positive (thickening) mainly in ONL and PR in AD. GCIPL of AD and MCI was thinner in superior, nasal superior, and temporal superior quadrants, compared to CN (p < 0.05). GCIPL of the inner superior, inner nasal superior, inner temporal superior, and outer nasal superior sectors was significantly thinner in AD than CN (p < 0.05). GCIPL of the outer superior, inner temporal superior, outer nasal, and temporal superior sectors was significantly thinner in MCI than CN (p < 0.05). CONCLUSION: Focal thinning of the GCIPL was visualized and quantified by detailed partitions in AD and MCI, which provides specific information about neurodegeneration in MCI and AD.",
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author = "Yi Shao and Hong Jiang and Yantao Wei and Yingying Shi and Ce Shi and Wright, {Clinton B.} and Xiaoyan Sun and Vanner, {Elizabeth A.} and Rodriguez, {Anny D.} and Lam, {Byron L} and Tatjana Rundek and Bernard Baumel and Gameiro, {Giovana Rosa} and Chuanhui Dong and Jianhua Wang",
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T1 - Visualization of Focal Thinning of the Ganglion Cell-Inner Plexiform Layer in Patients with Mild Cognitive Impairment and Alzheimer's Disease

AU - Shao, Yi

AU - Jiang, Hong

AU - Wei, Yantao

AU - Shi, Yingying

AU - Shi, Ce

AU - Wright, Clinton B.

AU - Sun, Xiaoyan

AU - Vanner, Elizabeth A.

AU - Rodriguez, Anny D.

AU - Lam, Byron L

AU - Rundek, Tatjana

AU - Baumel, Bernard

AU - Gameiro, Giovana Rosa

AU - Dong, Chuanhui

AU - Wang, Jianhua

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: A detailed analysis of the tomographic thickness of intraretinal layers may provide more information on neurodegeneration in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). OBJECTIVE: The goal was to analyze tomographic thickness patterns of intraretinal layers in patients with AD andMCI. METHOD: Forty-nine patients (25 AD and 24 MCI) and 21 cognitively normal (CN) controls were imaged using ultra-high-resolution optical coherence tomography to obtain volumetric data centered on the fovea. The segmented intraretinal layers were retinal nerve fiber layer (RNFL), ganglion cell- inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL), and retinal photoreceptor (PR), in addition to the total retinal thickness(TRT). RESULTS: The thickness differences were negative (thinning) mainly in TRT, RNFL, and GCIPL in both AD and MCI groups in comparison to CN, while the thickness differences were positive (thickening) mainly in ONL and PR in AD. GCIPL of AD and MCI was thinner in superior, nasal superior, and temporal superior quadrants, compared to CN (p < 0.05). GCIPL of the inner superior, inner nasal superior, inner temporal superior, and outer nasal superior sectors was significantly thinner in AD than CN (p < 0.05). GCIPL of the outer superior, inner temporal superior, outer nasal, and temporal superior sectors was significantly thinner in MCI than CN (p < 0.05). CONCLUSION: Focal thinning of the GCIPL was visualized and quantified by detailed partitions in AD and MCI, which provides specific information about neurodegeneration in MCI and AD.

AB - BACKGROUND: A detailed analysis of the tomographic thickness of intraretinal layers may provide more information on neurodegeneration in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). OBJECTIVE: The goal was to analyze tomographic thickness patterns of intraretinal layers in patients with AD andMCI. METHOD: Forty-nine patients (25 AD and 24 MCI) and 21 cognitively normal (CN) controls were imaged using ultra-high-resolution optical coherence tomography to obtain volumetric data centered on the fovea. The segmented intraretinal layers were retinal nerve fiber layer (RNFL), ganglion cell- inner plexiform layer (GCIPL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL), and retinal photoreceptor (PR), in addition to the total retinal thickness(TRT). RESULTS: The thickness differences were negative (thinning) mainly in TRT, RNFL, and GCIPL in both AD and MCI groups in comparison to CN, while the thickness differences were positive (thickening) mainly in ONL and PR in AD. GCIPL of AD and MCI was thinner in superior, nasal superior, and temporal superior quadrants, compared to CN (p < 0.05). GCIPL of the inner superior, inner nasal superior, inner temporal superior, and outer nasal superior sectors was significantly thinner in AD than CN (p < 0.05). GCIPL of the outer superior, inner temporal superior, outer nasal, and temporal superior sectors was significantly thinner in MCI than CN (p < 0.05). CONCLUSION: Focal thinning of the GCIPL was visualized and quantified by detailed partitions in AD and MCI, which provides specific information about neurodegeneration in MCI and AD.

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KW - ETDRS partition

KW - ganglion-inner plexiform layer

KW - hemispheric partition

KW - mild cognitive impairment

KW - retinal thickness mapping

KW - ultrahigh-resolution OCT

KW - Zeiss elliptical partition

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