Visual Object Discrimination Impairment as an Early Predictor of Mild Cognitive Impairment and Alzheimer's Disease

Leslie S. Gaynor, Rosie E. Curiel Cid, Ailyn Penate, Mónica Rosselli, Sara N. Burke, Meredith Wicklund, David A. Loewenstein, Russell M. Bauer

Research output: Contribution to journalArticle

Abstract

Objective: Detection of cognitive impairment suggestive of risk for Alzheimer's disease (AD) progression is crucial to the prevention of incipient dementia. This study was performed to determine if performance on a novel object discrimination task improved identification of earlier deficits in older adults at risk for AD. Method: In total, 135 participants from the 1Florida Alzheimer's Disease Research Center [cognitively normal (CN), Pre-mild cognitive impairment (PreMCI), amnestic mild cognitive impairment (aMCI), and dementia] completed a test of object discrimination and traditional memory measures in the context of a larger neuropsychological and clinical evaluation. Results: The Object Recognition and Discrimination Task (ORDT) revealed significant differences between the PreMCI, aMCI, and dementia groups versus CN individuals. Moreover, relative risk of being classified as PreMCI rather than CN increased as an inverse function of ORDT score. Discussion: Overall, the obtained results suggest that a novel object discrimination task improves the detection of very early AD-related cognitive impairment, increasing the window for therapeutic intervention. (JINS, 2019, xx, 000-000).

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJournal of the International Neuropsychological Society
DOIs
StatePublished - Jan 1 2019

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Keywords

  • Dementia
  • early diagnosis
  • memory
  • perirhinal cortex
  • temporal lobe
  • visual perception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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