Visual impairment in children with congenital Zika syndrome

Liana O. Ventura, Camila V. Ventura, Linda Lawrence, Vanessa van der Linden, Ana van der Linden, Adriana L. Gois, Milena M. Cavalcanti, Eveline A. Barros, Natalia C. Dias, Audina Berrocal, Marilyn T. Miller

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To describe the visual impairment associated with ocular and neurological abnormalities in a cohort of children with congenital Zika syndrome (CZS). Methods: This cross-sectional study included infants with microcephaly born in Pernambuco, Brazil, from May to December 2015. Immunoglobulin M antibody capture enzyme-linked immunosorbent assay for the Zika virus on the cerebrospinal fluid samples was positive for all infants. Clinical evaluation consisted of comprehensive ophthalmologic examination including visual acuity, visual function assessment, visual developmental milestone, neurologic examination, and neuroimaging. Results: A total of 32 infants (18 males [56%]) were included. Mean age at examination was 5.7 ± 0.9 months (range, 4-7 months). Visual function and visual developmental milestone could not be tested in 1 child (3%). Visual impairment was detected in 32 infants (100%). Retinal and/or optic nerve findings were observed in 14 patients (44%). There was no statistical difference between the patients with ocular findings and those without (P = 0.180). All patients (100%) demonstrated neurological and neuroimaging abnormalities; 3 (9%) presented with late-onset of microcephaly. Conclusions: Children with CZS demonstrated visual impairment regardless of retina and/or optic nerve abnormalities. This finding suggests that cortical/cerebral visual impairment may be the most common cause of blindness identified in children with CZS.

Original languageEnglish (US)
JournalJournal of AAPOS
DOIs
StateAccepted/In press - Nov 25 2016

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Vision Disorders
Microcephaly
Optic Nerve
Neuroimaging
Eye Abnormalities
Neurologic Examination
Blindness
Visual Acuity
Brazil
Immunoglobulin M
Cerebrospinal Fluid
Retina
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

Ventura, L. O., Ventura, C. V., Lawrence, L., van der Linden, V., van der Linden, A., Gois, A. L., ... Miller, M. T. (Accepted/In press). Visual impairment in children with congenital Zika syndrome. Journal of AAPOS. https://doi.org/10.1016/j.jaapos.2017.04.003

Visual impairment in children with congenital Zika syndrome. / Ventura, Liana O.; Ventura, Camila V.; Lawrence, Linda; van der Linden, Vanessa; van der Linden, Ana; Gois, Adriana L.; Cavalcanti, Milena M.; Barros, Eveline A.; Dias, Natalia C.; Berrocal, Audina; Miller, Marilyn T.

In: Journal of AAPOS, 25.11.2016.

Research output: Contribution to journalArticle

Ventura, LO, Ventura, CV, Lawrence, L, van der Linden, V, van der Linden, A, Gois, AL, Cavalcanti, MM, Barros, EA, Dias, NC, Berrocal, A & Miller, MT 2016, 'Visual impairment in children with congenital Zika syndrome', Journal of AAPOS. https://doi.org/10.1016/j.jaapos.2017.04.003
Ventura LO, Ventura CV, Lawrence L, van der Linden V, van der Linden A, Gois AL et al. Visual impairment in children with congenital Zika syndrome. Journal of AAPOS. 2016 Nov 25. https://doi.org/10.1016/j.jaapos.2017.04.003
Ventura, Liana O. ; Ventura, Camila V. ; Lawrence, Linda ; van der Linden, Vanessa ; van der Linden, Ana ; Gois, Adriana L. ; Cavalcanti, Milena M. ; Barros, Eveline A. ; Dias, Natalia C. ; Berrocal, Audina ; Miller, Marilyn T. / Visual impairment in children with congenital Zika syndrome. In: Journal of AAPOS. 2016.
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