TY - JOUR
T1 - Visual Function and Disability Are Associated with Increased Retinal Volumetric Vessel Density in Patients with Multiple Sclerosis
AU - Jiang, Hong
AU - Gameiro, Giovana Rosa
AU - Liu, Yi
AU - Lin, Ying
AU - Hernandez, Jeffrey
AU - Deng, Yuqing
AU - Gregori, Giovanni
AU - Delgado, Silvia
AU - Wang, Jianhua
N1 - Funding Information:
Funding/Support: This work has been supported by National Multiple Sclerosis Society , United States grant RG-1506-04890 , US National Institutes of Health , United States grant P30 EY014801 , and a grant from Research to Prevent Blindness , United States (to Bascom Palmer Eye Institute).
Funding Information:
All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none was reported. Funding/Support: This work has been supported by National Multiple Sclerosis Society, United States grant RG-1506-04890, US National Institutes of Health, United States grant P30 EY014801, and a grant from Research to Prevent Blindness, United States (to Bascom Palmer Eye Institute). Financial disclosures: Dr. Gregori has received research support from Carl Zeiss Meditec (Jena, Germany). Dr. Delgado is a consultant for Novartis (King of Prussia, Pennsylvania). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Contribution: Design of the study (H.J. Y.L. S.D. J.W.); data collection (H.J. G.R.G. Y.L. Y.L. H.J. Y.D. G.C. S.D. J.W.); analysis and interpretation of the data (H.J. G.R.G. Y.L. H.J. Y.L. Y.D. G.C. S.D. J.W.); preparation, review and approval of the manuscript (H.J. G.R.G. Y.L. H.J. Y.D. G.C. S.D. J.W.).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/5
Y1 - 2020/5
N2 - Purpose: The goal of this study was to determine the volumetric vessel density (VVD) in the intraretinal layers and its relationship with visual function and disability in patients with multiple sclerosis (MS). Design: Cross-sectional study. Methods: A total of 80 patients with relapsing-remitting MS and 99 age- and sex-matched healthy controls (HC) were recruited. The retinal microvascular network in the macular area was imaged using optical coherence tomography angiography in 123 eyes without a history of optic neuritis (ON) (MSNON) and 36 eyes with a history of ON (MSON). The VVD was calculated as the vessel densities in the retinal vascular network (RVN), superficial vascular plexus (SVP), or deep vascular plexus (DVP) of an annulus (0.6-2.5 mm in diameter), divided by the corresponding tissue volume of the intraretinal layers respectively. Results: The VVD of RVN and DVP in MSNON were significantly higher than in HC (P < .05). The VVD of RVN, SVP, and DVP in MSON were significantly higher than in MSNON and HC (P < .05). The VVD in both RVN and SVP were positively related to EDSS and disease duration, but negatively related to low-contrast letter acuity (P < .05). The VVD measurements were also negatively and strongly related to the corresponding tissue volumes (P < .05). Conclusions: This is the first study to reveal increased retinal VVD in patients with relapsing-remitting MS. The measurements of VVD in the RVN and SVP were related to disability and visual function, which may be developed as image markers for tracking disease progression.
AB - Purpose: The goal of this study was to determine the volumetric vessel density (VVD) in the intraretinal layers and its relationship with visual function and disability in patients with multiple sclerosis (MS). Design: Cross-sectional study. Methods: A total of 80 patients with relapsing-remitting MS and 99 age- and sex-matched healthy controls (HC) were recruited. The retinal microvascular network in the macular area was imaged using optical coherence tomography angiography in 123 eyes without a history of optic neuritis (ON) (MSNON) and 36 eyes with a history of ON (MSON). The VVD was calculated as the vessel densities in the retinal vascular network (RVN), superficial vascular plexus (SVP), or deep vascular plexus (DVP) of an annulus (0.6-2.5 mm in diameter), divided by the corresponding tissue volume of the intraretinal layers respectively. Results: The VVD of RVN and DVP in MSNON were significantly higher than in HC (P < .05). The VVD of RVN, SVP, and DVP in MSON were significantly higher than in MSNON and HC (P < .05). The VVD in both RVN and SVP were positively related to EDSS and disease duration, but negatively related to low-contrast letter acuity (P < .05). The VVD measurements were also negatively and strongly related to the corresponding tissue volumes (P < .05). Conclusions: This is the first study to reveal increased retinal VVD in patients with relapsing-remitting MS. The measurements of VVD in the RVN and SVP were related to disability and visual function, which may be developed as image markers for tracking disease progression.
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U2 - 10.1016/j.ajo.2019.12.021
DO - 10.1016/j.ajo.2019.12.021
M3 - Article
C2 - 31926161
AN - SCOPUS:85079590784
VL - 213
SP - 34
EP - 45
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -