Visual function and disability are associated with focal thickness reduction of the ganglion cell-inner plexiform layer in patients with multiple sclerosis

Ce Shi, Hong Jiang, Giovana Rosa Gameiro, Huiling Hu, Jeffrey Hernandez, Silvia Delgado, Jianhua Wang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

PURPOSE. The purpose of this study was to visualize the topographic thickness patterns of the intraretinal layers and their associations with clinical manifestations in patients with multiple sclerosis (MS). METHODS. Ninety-four eyes of 47 relapsing-remitting MS patients without history of optic neuritis were imaged using optical coherence tomography and compared with 134 eyes of 67 healthy subjects. Volumetric data centered on the fovea were segmented to obtain the thickness maps of six intraretinal layers. The thickness measurements partitioned using the Early Treatment Diabetic Retinopathy Study (ETDRS) partition were correlated to the Expanded Disability State Scale (EDSS) and Sloan low contrast visual acuity (LCVA). The receiver-operating characteristics (ROC) curves were calculated to obtain the area under the ROC curves (AUCs). RESULTS. The ganglion cell-inner plexiform layer (GCIPL) showed horseshoe-like thickness reduction profoundly at the nasal sector. The most profound thickness reduction zone (circular area, diameter = 1 mm) was located at 2 mm in the nasal sector and 0.4 mm inferior from the fovea, named the ‘‘M zone.’’ The thickness reduction of the M zone was -7.3 μm in MS eyes, which was the most profound alteration, compared to any ETDRS sectors. The AUC of the M zone was 0.75. The relationship between the thickness of the M zone and EDSS (r = -0.59, P < 0.001) or 2.5% LCVA (r = 0.51, P < 0.001) were ranked as the strongest relation compared to any ETDRS sectors. CONCLUSIONS. This is the first study, to our knowledge, to visualize focal thickness alteration of GCIPL and reveal its relationship to visual function and disability in patients with MS without history of optic neuritis.

Original languageEnglish (US)
Pages (from-to)1213-1223
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume60
Issue number4
DOIs
StatePublished - Mar 1 2019

Fingerprint

Diabetic Retinopathy
ROC Curve
Ganglia
Multiple Sclerosis
Optic Neuritis
Nose
Visual Acuity
Relapsing-Remitting Multiple Sclerosis
Optical Coherence Tomography
Area Under Curve
Healthy Volunteers
Therapeutics

Keywords

  • Disability
  • Ganglion cell-inner plexiform layer
  • Low-contrast visual acuity
  • Multiple sclerosis
  • Tomographic thickness

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Visual function and disability are associated with focal thickness reduction of the ganglion cell-inner plexiform layer in patients with multiple sclerosis. / Shi, Ce; Jiang, Hong; Gameiro, Giovana Rosa; Hu, Huiling; Hernandez, Jeffrey; Delgado, Silvia; Wang, Jianhua.

In: Investigative Ophthalmology and Visual Science, Vol. 60, No. 4, 01.03.2019, p. 1213-1223.

Research output: Contribution to journalArticle

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abstract = "PURPOSE. The purpose of this study was to visualize the topographic thickness patterns of the intraretinal layers and their associations with clinical manifestations in patients with multiple sclerosis (MS). METHODS. Ninety-four eyes of 47 relapsing-remitting MS patients without history of optic neuritis were imaged using optical coherence tomography and compared with 134 eyes of 67 healthy subjects. Volumetric data centered on the fovea were segmented to obtain the thickness maps of six intraretinal layers. The thickness measurements partitioned using the Early Treatment Diabetic Retinopathy Study (ETDRS) partition were correlated to the Expanded Disability State Scale (EDSS) and Sloan low contrast visual acuity (LCVA). The receiver-operating characteristics (ROC) curves were calculated to obtain the area under the ROC curves (AUCs). RESULTS. The ganglion cell-inner plexiform layer (GCIPL) showed horseshoe-like thickness reduction profoundly at the nasal sector. The most profound thickness reduction zone (circular area, diameter = 1 mm) was located at 2 mm in the nasal sector and 0.4 mm inferior from the fovea, named the ‘‘M zone.’’ The thickness reduction of the M zone was -7.3 μm in MS eyes, which was the most profound alteration, compared to any ETDRS sectors. The AUC of the M zone was 0.75. The relationship between the thickness of the M zone and EDSS (r = -0.59, P < 0.001) or 2.5{\%} LCVA (r = 0.51, P < 0.001) were ranked as the strongest relation compared to any ETDRS sectors. CONCLUSIONS. This is the first study, to our knowledge, to visualize focal thickness alteration of GCIPL and reveal its relationship to visual function and disability in patients with MS without history of optic neuritis.",
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T1 - Visual function and disability are associated with focal thickness reduction of the ganglion cell-inner plexiform layer in patients with multiple sclerosis

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AU - Jiang, Hong

AU - Gameiro, Giovana Rosa

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AU - Hernandez, Jeffrey

AU - Delgado, Silvia

AU - Wang, Jianhua

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N2 - PURPOSE. The purpose of this study was to visualize the topographic thickness patterns of the intraretinal layers and their associations with clinical manifestations in patients with multiple sclerosis (MS). METHODS. Ninety-four eyes of 47 relapsing-remitting MS patients without history of optic neuritis were imaged using optical coherence tomography and compared with 134 eyes of 67 healthy subjects. Volumetric data centered on the fovea were segmented to obtain the thickness maps of six intraretinal layers. The thickness measurements partitioned using the Early Treatment Diabetic Retinopathy Study (ETDRS) partition were correlated to the Expanded Disability State Scale (EDSS) and Sloan low contrast visual acuity (LCVA). The receiver-operating characteristics (ROC) curves were calculated to obtain the area under the ROC curves (AUCs). RESULTS. The ganglion cell-inner plexiform layer (GCIPL) showed horseshoe-like thickness reduction profoundly at the nasal sector. The most profound thickness reduction zone (circular area, diameter = 1 mm) was located at 2 mm in the nasal sector and 0.4 mm inferior from the fovea, named the ‘‘M zone.’’ The thickness reduction of the M zone was -7.3 μm in MS eyes, which was the most profound alteration, compared to any ETDRS sectors. The AUC of the M zone was 0.75. The relationship between the thickness of the M zone and EDSS (r = -0.59, P < 0.001) or 2.5% LCVA (r = 0.51, P < 0.001) were ranked as the strongest relation compared to any ETDRS sectors. CONCLUSIONS. This is the first study, to our knowledge, to visualize focal thickness alteration of GCIPL and reveal its relationship to visual function and disability in patients with MS without history of optic neuritis.

AB - PURPOSE. The purpose of this study was to visualize the topographic thickness patterns of the intraretinal layers and their associations with clinical manifestations in patients with multiple sclerosis (MS). METHODS. Ninety-four eyes of 47 relapsing-remitting MS patients without history of optic neuritis were imaged using optical coherence tomography and compared with 134 eyes of 67 healthy subjects. Volumetric data centered on the fovea were segmented to obtain the thickness maps of six intraretinal layers. The thickness measurements partitioned using the Early Treatment Diabetic Retinopathy Study (ETDRS) partition were correlated to the Expanded Disability State Scale (EDSS) and Sloan low contrast visual acuity (LCVA). The receiver-operating characteristics (ROC) curves were calculated to obtain the area under the ROC curves (AUCs). RESULTS. The ganglion cell-inner plexiform layer (GCIPL) showed horseshoe-like thickness reduction profoundly at the nasal sector. The most profound thickness reduction zone (circular area, diameter = 1 mm) was located at 2 mm in the nasal sector and 0.4 mm inferior from the fovea, named the ‘‘M zone.’’ The thickness reduction of the M zone was -7.3 μm in MS eyes, which was the most profound alteration, compared to any ETDRS sectors. The AUC of the M zone was 0.75. The relationship between the thickness of the M zone and EDSS (r = -0.59, P < 0.001) or 2.5% LCVA (r = 0.51, P < 0.001) were ranked as the strongest relation compared to any ETDRS sectors. CONCLUSIONS. This is the first study, to our knowledge, to visualize focal thickness alteration of GCIPL and reveal its relationship to visual function and disability in patients with MS without history of optic neuritis.

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KW - Multiple sclerosis

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