Vision loss after intravitreal injection of autologous "stem Cells" for AMD

Ajay Kuriyan, Thomas A Albini, Justin Townsend, Marianeli Rodriguez, Hemang K. Pandya, Robert E. Leonard, M. Brandon Parrott, Philip J Rosenfeld, Harry W Flynn, Jeffrey L. Goldberg

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients' visual acuity ranged from 20/200 to no light perception.

Original languageEnglish (US)
Pages (from-to)1047-1053
Number of pages7
JournalNew England Journal of Medicine
Volume376
Issue number11
DOIs
StatePublished - Mar 16 2017

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Intravitreal Injections
Stem Cells
Visual Acuity
Adipose Tissue
Lens Subluxation
Patient Acuity
Vitreous Hemorrhage
Ocular Hypertension
Injections
Traction
Retinal Detachment
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vision loss after intravitreal injection of autologous "stem Cells" for AMD. / Kuriyan, Ajay; Albini, Thomas A; Townsend, Justin; Rodriguez, Marianeli; Pandya, Hemang K.; Leonard, Robert E.; Parrott, M. Brandon; Rosenfeld, Philip J; Flynn, Harry W; Goldberg, Jeffrey L.

In: New England Journal of Medicine, Vol. 376, No. 11, 16.03.2017, p. 1047-1053.

Research output: Contribution to journalArticle

Kuriyan, Ajay ; Albini, Thomas A ; Townsend, Justin ; Rodriguez, Marianeli ; Pandya, Hemang K. ; Leonard, Robert E. ; Parrott, M. Brandon ; Rosenfeld, Philip J ; Flynn, Harry W ; Goldberg, Jeffrey L. / Vision loss after intravitreal injection of autologous "stem Cells" for AMD. In: New England Journal of Medicine. 2017 ; Vol. 376, No. 11. pp. 1047-1053.
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