Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

Xiangyang Zhang, Jianming Hu, Robert W. Knighton, XiangRun Huang, Carmen A. Puliafito, Shuliang Jiao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength (<560nm) is reduced much more than that at long wavelength, which provides spectral contrasts for imaging the earliest damage to the RNFL. To image the spectral contrasts we built a dual-band spectral-domain optical coherence tomography (SD-OCT) with centered wavelength of 415nm (VIS) and 808nm (NIR), respectively. The light at the two bands was provided by the fundamental and frequency-doubled outputs of a broadband Ti: Sapphire laser. The depth resolutions of the VIS and NIR OCT systems are 12.2μm and 4.7μm in the air. The system was applied to imaging the rat retina in vivo. Significantly different appearances between the OCT cross sectional images at the two bands are observed. The experimental results showed that the dual-band OCT system is feasible for imaging the spectral contrasts of the RNFL.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8213
ISBN (Print)9780819488565
DOIs
StatePublished - Jan 1 2012
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Fingerprint

nerve fibers
Optical tomography
Optical Coherence Tomography
Nerve Fibers
tomography
Imaging techniques
Light
Fibers
Wavelength
wavelengths
glaucoma
damage
Aluminum Oxide
retina
spectral bands
Sapphire
Glaucoma
rats
Retina
Rats

Keywords

  • Glaucoma
  • Optical coherent tomography
  • Reflectance
  • Retinal nerve fiber layer

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Zhang, X., Hu, J., Knighton, R. W., Huang, X., Puliafito, C. A., & Jiao, S. (2012). Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8213). [82130H] SPIE. https://doi.org/10.1117/12.909525

Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer. / Zhang, Xiangyang; Hu, Jianming; Knighton, Robert W.; Huang, XiangRun; Puliafito, Carmen A.; Jiao, Shuliang.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213 SPIE, 2012. 82130H.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhang, X, Hu, J, Knighton, RW, Huang, X, Puliafito, CA & Jiao, S 2012, Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8213, 82130H, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, San Francisco, CA, United States, 1/23/12. https://doi.org/10.1117/12.909525
Zhang X, Hu J, Knighton RW, Huang X, Puliafito CA, Jiao S. Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213. SPIE. 2012. 82130H https://doi.org/10.1117/12.909525
Zhang, Xiangyang ; Hu, Jianming ; Knighton, Robert W. ; Huang, XiangRun ; Puliafito, Carmen A. ; Jiao, Shuliang. / Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8213 SPIE, 2012.
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