Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets

Zahra Nafar, Rong Wen, Shuliang Jiao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image. With the OCT and fluorescence images of the reference targets, the effects of illumination power and detector sensitivity can be eliminated.

Original languageEnglish (US)
Article number335557
Pages (from-to)3768-3782
Number of pages15
JournalBiomedical Optics Express
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2018

Fingerprint

Lipofuscin
epithelium
Retinal Pigment Epithelium
pigments
tomography
Optical Coherence Tomography
Technology
Light
fluorescence
retina
Fluorescence
attenuation
illumination
Lighting
reflectance
Retina
detectors

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets. / Nafar, Zahra; Wen, Rong; Jiao, Shuliang.

In: Biomedical Optics Express, Vol. 9, No. 8, 335557, 01.08.2018, p. 3768-3782.

Research output: Contribution to journalArticle

@article{0daaadb9345d43a1b20d4543f5f62dee,
title = "Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets",
abstract = "We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image. With the OCT and fluorescence images of the reference targets, the effects of illumination power and detector sensitivity can be eliminated.",
author = "Zahra Nafar and Rong Wen and Shuliang Jiao",
year = "2018",
month = "8",
day = "1",
doi = "10.1364/BOE.9.003768",
language = "English (US)",
volume = "9",
pages = "3768--3782",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "8",

}

TY - JOUR

T1 - Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets

AU - Nafar, Zahra

AU - Wen, Rong

AU - Jiao, Shuliang

PY - 2018/8/1

Y1 - 2018/8/1

N2 - We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image. With the OCT and fluorescence images of the reference targets, the effects of illumination power and detector sensitivity can be eliminated.

AB - We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image. With the OCT and fluorescence images of the reference targets, the effects of illumination power and detector sensitivity can be eliminated.

UR - http://www.scopus.com/inward/record.url?scp=85051288724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051288724&partnerID=8YFLogxK

U2 - 10.1364/BOE.9.003768

DO - 10.1364/BOE.9.003768

M3 - Article

AN - SCOPUS:85051288724

VL - 9

SP - 3768

EP - 3782

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 8

M1 - 335557

ER -