Visible light OCT-based quantitative imaging of lipofuscin in the retinal pigment epithelium with standard reference targets

Zahra Nafar, Rong Wen, Shuliang Jiao

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We developed a technology for quantitative retinal autofluorescence (AF, or FAF for fundus AF) imaging for quantifying lipofuscin in the retinal pigment epithelium (RPE). The technology is based on simultaneous visible light optical coherence tomography (VIS-OCT) and AF imaging of the retina and a pair of reference standard targets at the intermediate retinal imaging plane with known reflectivity for the OCT and fluorescence efficiency for the FAF. The technology is able to eliminate the pre-RPE attenuation in FAF imaging by using the simultaneously acquired VIS-OCT image. With the OCT and fluorescence images of the reference targets, the effects of illumination power and detector sensitivity can be eliminated.

Original languageEnglish (US)
Article number335557
Pages (from-to)3768-3782
Number of pages15
JournalBiomedical Optics Express
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2018

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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