Abstract
OBJECTIVE - This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age. RESEARCH DESIGN AND METHODS - Measurements of body composition (dual-energy X-ray absorptiometry), body fat distribution (computed tomography), fasting and 2-h postprandial (75-g) glucose concentrations, and fasting lipoprotein lipid and insulin concentrations were performed in 233 perimenopausal (9%) and postmenopausal women (age 59 ± 6 years, 79% Caucasian, 16% on hormone replacement therapy). RESULTS - Women in the lowest VAT quintile (≤105 cm2) had higher concentrations of HDL and HDL2 cholesterol, lower LDL/HDL cholesterol ratios and triglyceride concentrations, and lower fasting glucose and insulin concentrations than women in the remaining four quintiles (P values <0.05-0.001). Women in the second lowest VAT quintile (106-139 cm2) had higher HDL and HDL2 cholesterol and lower LDL/HDL ratios than women with a VAT ≥163 cm2 (P < 0.05). Logistic regression analyses showed that women with a VAT of 106-162 cm2 are 2.5 times more likely to have a low HDL cholesterol (P < 0.05), while women with a VAT ≥163 cm2 are 5.5 times more likely to have a low HDL cholesterol (P < 0.01) and ∼4.0 times more likely to have a high LDL/HDL ratio (P < 0.05) compared with women with a VAT ≥105 cm2. Women with a VAT ≥163 cm2 are at a higher risk of having impaired glucose tolerance (P < 0.01). CONCLUSIONS - A VAT ≥106 cm2 is associated with an elevated risk, and a VAT ≥163 cm2 with an even greater risk, for these metabolic CHD risk factors compared with women with a VAT ≤105 cm2. These values may prove useful for defining "visceral obesity" and for identifying women most likely to benefit from preventative interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 1413-1420 |
| Number of pages | 8 |
| Journal | Diabetes Care |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women. / Nicklas, Barbara J.; Penninx, Brenda W J H; Ryan, Alice S.; Berman-Weinberg, Dora; Lynch, Nicole A.; Dennis, Karen E.
In: Diabetes Care, Vol. 26, No. 5, 01.05.2003, p. 1413-1420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women
AU - Nicklas, Barbara J.
AU - Penninx, Brenda W J H
AU - Ryan, Alice S.
AU - Berman-Weinberg, Dora
AU - Lynch, Nicole A.
AU - Dennis, Karen E.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - OBJECTIVE - This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age. RESEARCH DESIGN AND METHODS - Measurements of body composition (dual-energy X-ray absorptiometry), body fat distribution (computed tomography), fasting and 2-h postprandial (75-g) glucose concentrations, and fasting lipoprotein lipid and insulin concentrations were performed in 233 perimenopausal (9%) and postmenopausal women (age 59 ± 6 years, 79% Caucasian, 16% on hormone replacement therapy). RESULTS - Women in the lowest VAT quintile (≤105 cm2) had higher concentrations of HDL and HDL2 cholesterol, lower LDL/HDL cholesterol ratios and triglyceride concentrations, and lower fasting glucose and insulin concentrations than women in the remaining four quintiles (P values <0.05-0.001). Women in the second lowest VAT quintile (106-139 cm2) had higher HDL and HDL2 cholesterol and lower LDL/HDL ratios than women with a VAT ≥163 cm2 (P < 0.05). Logistic regression analyses showed that women with a VAT of 106-162 cm2 are 2.5 times more likely to have a low HDL cholesterol (P < 0.05), while women with a VAT ≥163 cm2 are 5.5 times more likely to have a low HDL cholesterol (P < 0.01) and ∼4.0 times more likely to have a high LDL/HDL ratio (P < 0.05) compared with women with a VAT ≥105 cm2. Women with a VAT ≥163 cm2 are at a higher risk of having impaired glucose tolerance (P < 0.01). CONCLUSIONS - A VAT ≥106 cm2 is associated with an elevated risk, and a VAT ≥163 cm2 with an even greater risk, for these metabolic CHD risk factors compared with women with a VAT ≤105 cm2. These values may prove useful for defining "visceral obesity" and for identifying women most likely to benefit from preventative interventions.
AB - OBJECTIVE - This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age. RESEARCH DESIGN AND METHODS - Measurements of body composition (dual-energy X-ray absorptiometry), body fat distribution (computed tomography), fasting and 2-h postprandial (75-g) glucose concentrations, and fasting lipoprotein lipid and insulin concentrations were performed in 233 perimenopausal (9%) and postmenopausal women (age 59 ± 6 years, 79% Caucasian, 16% on hormone replacement therapy). RESULTS - Women in the lowest VAT quintile (≤105 cm2) had higher concentrations of HDL and HDL2 cholesterol, lower LDL/HDL cholesterol ratios and triglyceride concentrations, and lower fasting glucose and insulin concentrations than women in the remaining four quintiles (P values <0.05-0.001). Women in the second lowest VAT quintile (106-139 cm2) had higher HDL and HDL2 cholesterol and lower LDL/HDL ratios than women with a VAT ≥163 cm2 (P < 0.05). Logistic regression analyses showed that women with a VAT of 106-162 cm2 are 2.5 times more likely to have a low HDL cholesterol (P < 0.05), while women with a VAT ≥163 cm2 are 5.5 times more likely to have a low HDL cholesterol (P < 0.01) and ∼4.0 times more likely to have a high LDL/HDL ratio (P < 0.05) compared with women with a VAT ≥105 cm2. Women with a VAT ≥163 cm2 are at a higher risk of having impaired glucose tolerance (P < 0.01). CONCLUSIONS - A VAT ≥106 cm2 is associated with an elevated risk, and a VAT ≥163 cm2 with an even greater risk, for these metabolic CHD risk factors compared with women with a VAT ≤105 cm2. These values may prove useful for defining "visceral obesity" and for identifying women most likely to benefit from preventative interventions.
UR - http://www.scopus.com/inward/record.url?scp=0041667936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041667936&partnerID=8YFLogxK
U2 - 10.2337/diacare.26.5.1413
DO - 10.2337/diacare.26.5.1413
M3 - Article
C2 - 12716798
AN - SCOPUS:0041667936
VL - 26
SP - 1413
EP - 1420
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 5
ER -