Abstract
Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis.
| Original language | English |
|---|---|
| Pages (from-to) | 1270-1276 |
| Number of pages | 7 |
| Journal | Nature Medicine |
| Volume | 5 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. / Evans, David T.; O'Connor, David H.; Jing, Peicheng; Dzuris, John L.; Sidney, John; Da Silva, Jack; Allen, Todd M.; Horton, Helen; Venham, John E.; Rudersdorf, Richard A.; Vogel, Thorsten; Pauza, C. David; Bontrop, Ronald E.; Demars, Robert; Sette, Alessandro; Hughes, Austin L.; Watkins, David.
In: Nature Medicine, Vol. 5, No. 11, 01.11.1999, p. 1270-1276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
AU - Evans, David T.
AU - O'Connor, David H.
AU - Jing, Peicheng
AU - Dzuris, John L.
AU - Sidney, John
AU - Da Silva, Jack
AU - Allen, Todd M.
AU - Horton, Helen
AU - Venham, John E.
AU - Rudersdorf, Richard A.
AU - Vogel, Thorsten
AU - Pauza, C. David
AU - Bontrop, Ronald E.
AU - Demars, Robert
AU - Sette, Alessandro
AU - Hughes, Austin L.
AU - Watkins, David
PY - 1999/11/1
Y1 - 1999/11/1
N2 - Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis.
AB - Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis.
UR - http://www.scopus.com/inward/record.url?scp=0032697315&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032697315&partnerID=8YFLogxK
U2 - 10.1038/15224
DO - 10.1038/15224
M3 - Article
C2 - 10545993
AN - SCOPUS:0032697315
VL - 5
SP - 1270
EP - 1276
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 11
ER -