Virus infections: Lessons from pancreas histology

Francesco Dotta, Letizia Galleri, Guido Sebastiani, Francesco Vendrame

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Type 1 diabetes mellitus is a chronic autoimmune disease resulting from the progressive immune-mediated destruction of pancreatic β cells in genetically susceptible individuals, with the likely contribution of environmental factors, among which viruses have been extensively studied. The pathologic hallmark of the disease is insulitis-a process characterized by islet infiltration of immunocompetent cells that has been well characterized in animal models of islet autoimmunity, and to a lesser extent, in humans. Insulitis characterization has provided valuable information to gain insights into the disease pathogenesis. We review the recent literature on the viral contribution to β-cell destruction and dysfunction in type 1 diabetes, with particular reference to the pathology of the pancreatic islet in humans and in animal models of the disease.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalCurrent diabetes reports
Volume10
Issue number5
DOIs
StatePublished - Oct 2010

Keywords

  • Animal models
  • Autoimmune response
  • Chemokines
  • Cytokines
  • ER stress
  • Insulitis
  • Pancreatic islet
  • Toll-like receptors
  • Type 1 diabetes
  • Viruses

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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