Virtual electrophysiological study in a 3-dimensional cardiac magnetic resonance imaging model of porcine myocardial infarction

Jason Ng, Jason T. Jacobson, Justin K. Ng, David Gordon, Daniel C. Lee, James C. Carr, Jeffrey Goldberger

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objectives: This study sought to test the hypothesis that "virtual" electrophysiological studies (EPS) on an anatomic platform generated by 3-dimensional magnetic resonance imaging reconstruction of the left ventricle can reproduce the reentrant circuits of induced ventricular tachycardia (VT) in a porcine model of myocardial infarction. Background: Delayed-enhancement magnetic resonance imaging has been used to characterize myocardial infarction and "gray zones," which are thought to reflect heterogeneous regions of viable and nonviable myocytes. Methods: Myocardial infarction by coronary artery occlusion was induced in 8 pigs. After a recovery period, 3-dimensional cardiac magnetic resonance images were obtained from each pig in vivo. Normal areas, gray zones, and infarct cores were classified based on voxel intensity. In the computer model, gray zones were assigned slower conduction and longer action potential durations than those for normal myocardium. Virtual EPS was performed and compared with results of actual in vivo programmed stimulation and noncontact mapping. Results: The left ventricular volumes ranged from 97.8 to 166.2 cm 3, with 4.9% to 17.5% of voxels classified as infarct zones. Six of the 7 pigs in which VT developed during actual EPS were also inducible with virtual EPS. Four of the 6 pigs that had simulated VT had reentrant circuits that approximated the circuits seen with noncontact mapping, whereas the remaining 2 had similar circuits but propagating in opposite directions. Conclusions: This initial study demonstrates the feasibility of applying a mathematical model to magnetic resonance imaging reconstructions of the left ventricle to predict VT circuits. Virtual EPS may be helpful to plan catheter ablation strategies or to identify patients who are at risk of future episodes of VT.

Original languageEnglish (US)
Pages (from-to)423-430
Number of pages8
JournalJournal of the American College of Cardiology
Volume60
Issue number5
DOIs
StatePublished - Jul 31 2012
Externally publishedYes

Fingerprint

Ventricular Tachycardia
Swine
Myocardial Infarction
Magnetic Resonance Imaging
Heart Ventricles
Catheter Ablation
Coronary Occlusion
Feasibility Studies
Computer Simulation
Muscle Cells
Action Potentials
Coronary Vessels
Myocardium
Theoretical Models
Magnetic Resonance Spectroscopy

Keywords

  • computer-based model
  • magnetic resonance imaging
  • myocardial infarction
  • ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Virtual electrophysiological study in a 3-dimensional cardiac magnetic resonance imaging model of porcine myocardial infarction. / Ng, Jason; Jacobson, Jason T.; Ng, Justin K.; Gordon, David; Lee, Daniel C.; Carr, James C.; Goldberger, Jeffrey.

In: Journal of the American College of Cardiology, Vol. 60, No. 5, 31.07.2012, p. 423-430.

Research output: Contribution to journalArticle

Ng, Jason ; Jacobson, Jason T. ; Ng, Justin K. ; Gordon, David ; Lee, Daniel C. ; Carr, James C. ; Goldberger, Jeffrey. / Virtual electrophysiological study in a 3-dimensional cardiac magnetic resonance imaging model of porcine myocardial infarction. In: Journal of the American College of Cardiology. 2012 ; Vol. 60, No. 5. pp. 423-430.
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