Virologic suppression, treatment adherence, and improved quality of life on a once-daily efavirenz-based regimen in treatment-naïve HIV-1-infected patients over 96 weeks

Dushyantha Jayaweera, Edwin Dejesus, Kim L. Nguyen, Kristy Grimm, David Butcher, Daniel W. Seekins

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Purpose: This study evaluated the long-term efficacy, safety, adherence, and quality of life (QoL) of a once-daily efavirenz-based antiretroviral regimen in two 96-week prospective open-label single-arm studies of treatment-naïve HIV-1-infected patients. Methods: Patients received once-daily efavirenz 600 mg and lamivudine 300 mg with either enteric-coated didanosine 400 mg (Daily Antiretroviral Therapy trial [DART] I) or extended-release stavudine 100 mg (DART II). The primary efficacy outcome measure was HIV RNA <400 copies/mL at Week 48. Results: In an intent-to-treat (ITT) analysis, HIV RNA level <400 (<50) copies/mL was reached by 82%(80%) and 74% (72%) of patients at Week 48 in DART I and II. At Week 96, the corresponding values were 74% (68%) and 55% (54%), respectively. Both regimens were well tolerated. There were no discontinuations for virologic failure. Medication adherence assessed by pill counts was above 80% in 90% of the patients in DART I and more than 80% of patients in DART II. Treatment produced a significant improvement in overall QoL. Conclusion: Once-daily efavirenz-based antiretroviral therapy was effective, durable, and well tolerated. In this study, a high level of adherence was achieved with improvement in overall QoL.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
JournalHIV Clinical Trials
Volume10
Issue number6
DOIs
StatePublished - Jan 1 2009

Keywords

  • Adherence
  • Efavirenz
  • HIV-1
  • Quality of life

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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