Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques

Zdenek Hel, David Venzon, Monita Poudyal, Wen Po Tsai, Laura Giuliani, Ruth Woodward, Claire Chougnet, Gene Shearer, John D. Altman, David Watkins, Norbert Bischofberger, Alashle Abimiku, Phillip Markham, James Tartaglia, Genoveffa Franchini

Research output: Contribution to journalArticle

177 Scopus citations

Abstract

Prolonged antiretrovirol therapy (ART) is not likely to eradicate human immunodeficiency virus type I (HIV-I) infection. Here we explore the effect of therapeutic immunization in the context of ART during primary infection using the simian immunodeficiency virus (SIV251) macaque model. Vaccination of rhesus macaques with the highly attenuated poxvirus-based NYVAC-SIV vaccine expressing structural genes elicited vigorous virus-specific CD4+ and CD8+ T cell responses in macaques that responded effectively to ART. Following discontinuation of a six-month ART regimen, viral rebound occurred in most animals, but was transient in six of eight vaccinated animals. Viral rebound was also transient in four of seven mock-vaccinated control animals. These data establish the importance of antiretroviral treatment during primary infection and demonstrate that virus-specific immune responses in the infected host can be expanded by therapeutic immunization.

Original languageEnglish (US)
Pages (from-to)1140-1146
Number of pages7
JournalNature medicine
Volume6
Issue number10
DOIs
StatePublished - Nov 2 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Hel, Z., Venzon, D., Poudyal, M., Tsai, W. P., Giuliani, L., Woodward, R., Chougnet, C., Shearer, G., Altman, J. D., Watkins, D., Bischofberger, N., Abimiku, A., Markham, P., Tartaglia, J., & Franchini, G. (2000). Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques. Nature medicine, 6(10), 1140-1146. https://doi.org/10.1038/80481