Viral, bacterial, and parasitic causes of liver disease

G. Carre, Eugene R Schiff

Research output: Contribution to journalArticle

Abstract

Advances continue in the field of viral hepatitis. The identification of receptors for hepatitis A virus will lead to a better understanding of its pathogenesis and perhaps to the development of new diagnostic and therapeutic strategies. Nevertheless, prevention of hepatitis A on a worldwide basis will come with the availability of inactivated vaccines. Implementation of universal vaccination for hepatitis B virus will reduce the number of acute and chronic cases and the risk for developing hepatocellular carcinoma. For those with chronic hepatitis B virus infection, interferon-α treatment has proven effective. Immune selection, a consequence of vaccine programs and antiviral therapy, has probably contributed to the emergence of mutant forms of hepatitis B virus. Hepatitis D virus, previously considered a defective virus requiring coinfection with hepatitis B virus to thrive, was shown to replicate in immunosuppressed patients undergoing organ transplantation without clinical evidence of infection. Hepatitis E virus has now been reported in the United States, primarily in tourists or immigrants coming from endemic areas. Parasitic infections remain an important cause of morbidity in tropical and subtropical regions. Finally, new bacteria continue to be identified in the pathogenesis of liver disease, especially among patients with acquired immunodeficiency syndrome.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume9
Issue number3
StatePublished - Jan 1 1993

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Parasitic Liver Diseases
Hepatitis B virus
Hepatitis Delta Virus
Hepatitis E virus
Defective Viruses
Hepatitis A virus
Parasitic Diseases
Inactivated Vaccines
Hepatitis A
Chronic Hepatitis B
Organ Transplantation
Virus Diseases
Coinfection
Interferons
Hepatitis
Antiviral Agents
Liver Diseases
Hepatocellular Carcinoma
Vaccination
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Viral, bacterial, and parasitic causes of liver disease. / Carre, G.; Schiff, Eugene R.

In: Current Opinion in Gastroenterology, Vol. 9, No. 3, 01.01.1993, p. 349-354.

Research output: Contribution to journalArticle

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