TY - JOUR
T1 - Vinblastine (VLB), bleomycin (BLEO), cis‐diamminedichloroplatinum (DDP) in disseminated extragonadal germ cell tumors. A southwest oncology group study
AU - Feun, Lynn G.
AU - Samson, Michael K.
AU - Stephens, Ronald L.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1980/5/15
Y1 - 1980/5/15
N2 - Nineteen patients considered to have metastatic primary extragonadal germ cell cancer were entered on a phase II chemotherapy study using as induction therapy a combination of vinblastine (VLB) 12 mg/m2 day 1, bleomycin (BLEO) 15 U/m2 i.v. or i.m. twice weekly, and cis-diamminedichloroplatinum (DDP) 15 mg/m2 days 1-5, with vinblastine and DDP repeated at 28-day intervals for 4 mth. All complete or partial responders were then placed on a maintenance regimen of vinblastine 12 mg/m2 alternating monthly with actinomycin-D 1.5 mg/m2 day 29, and chlorambucil, 10 mg/m2 P.O. days 32-37. There were three complete remissions (CR's), 6 partial remissions (PR's), and 2 stable disease. The response rate (CR's + PR's) was 56%; however, the mean duration of response was only 2 mth (range, 1-8 mth). Drug toxicity was significant and there was one toxic death. Unlike patients with disseminated testicular cancer, patients with primary metastatic extragonadal germ cell carcinoma appear to do less well on this particular drug regimen. Further investigation using different drug regimens seems necessary.
AB - Nineteen patients considered to have metastatic primary extragonadal germ cell cancer were entered on a phase II chemotherapy study using as induction therapy a combination of vinblastine (VLB) 12 mg/m2 day 1, bleomycin (BLEO) 15 U/m2 i.v. or i.m. twice weekly, and cis-diamminedichloroplatinum (DDP) 15 mg/m2 days 1-5, with vinblastine and DDP repeated at 28-day intervals for 4 mth. All complete or partial responders were then placed on a maintenance regimen of vinblastine 12 mg/m2 alternating monthly with actinomycin-D 1.5 mg/m2 day 29, and chlorambucil, 10 mg/m2 P.O. days 32-37. There were three complete remissions (CR's), 6 partial remissions (PR's), and 2 stable disease. The response rate (CR's + PR's) was 56%; however, the mean duration of response was only 2 mth (range, 1-8 mth). Drug toxicity was significant and there was one toxic death. Unlike patients with disseminated testicular cancer, patients with primary metastatic extragonadal germ cell carcinoma appear to do less well on this particular drug regimen. Further investigation using different drug regimens seems necessary.
UR - http://www.scopus.com/inward/record.url?scp=0018900530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018900530&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19800515)45:10<2543::AID-CNCR2820451012>3.0.CO;2-H
DO - 10.1002/1097-0142(19800515)45:10<2543::AID-CNCR2820451012>3.0.CO;2-H
M3 - Article
C2 - 6155194
AN - SCOPUS:0018900530
VL - 45
SP - 2543
EP - 2549
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 10
ER -