Abstract
One hundred sixty-five patients were randomized to receive either Interferon alfa-n1 (Wellferon; Burroughs Wellcome Co, Research Triangle Park, NC) alone or with vinblastine. An initial six-cycle induction treatment consisted of Interferon given at daily doses of 3, 5, 20, 20, and 20 × 106 U/m2 every 2 weeks. Vinblastine at a dose of 10 mg/2 (later decreased to 5 mg/2) was given on day 1 of alternate cycles. Toxicities were generally well tolerated. The overall response rate was 10% with no significant difference between treatment arms. Survival was also not significantly different for the arms. A small subset of patients (16) with metastases only to the lungs had a high complete response (CR) and partial response (PR) rate of 44%. Responses were durable, and overall survival of this group was much better than that of the other patients.
Original language | English (US) |
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Pages (from-to) | 832-837 |
Number of pages | 6 |
Journal | Journal of Clinical Oncology |
Volume | 9 |
Issue number | 5 |
DOIs | |
State | Published - 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research