Vesicular stomatitis virus (VSV) therapy of tumors

S. Balachandran, Glen N Barber

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Vesicular stomatitis virus (VSV) is an essentially nonpathogenic negative-stranded RNA virus, the replication of which is extremely sensitive to the antiviral effects of interferon (IFN). We demonstrate here that VSV selectively induces the cytolysis of numerous transformed human cell lines in vitro, with all the morphological characteristics of apoptotic cell death. Importantly, VSV can also potently inhibit the growth of p53-null C6 glioblastoma tumors in vivo without infecting and replicating in normal tissue. With our previous findings demonstrating that primary cells containing the double-stranded RNA-activated protein kinase PKR and a functional IFN system are not permissive to VSV replication, these results suggest that signaling by IFN may be defective in many malignancies. Thus VSV might be useful in novel therapeutic strategies for targeting neoplastic disease.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalIUBMB Life
Volume50
Issue number2
StatePublished - Dec 18 2000

Fingerprint

Oncogenic Viruses
Vesicular Stomatitis
Viruses
Tumors
eIF-2 Kinase
Interferons
Virus Replication
Therapeutics
Transformed Cell Line
Double-Stranded RNA
RNA Viruses
Glioblastoma
Antiviral Agents
Cell death
Neoplasms
Cell Death
Cells
RNA
Tissue
Growth

Keywords

  • Interferon
  • Oncolytic virus
  • PKR
  • Tumor
  • VSV

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Vesicular stomatitis virus (VSV) therapy of tumors. / Balachandran, S.; Barber, Glen N.

In: IUBMB Life, Vol. 50, No. 2, 18.12.2000, p. 135-138.

Research output: Contribution to journalArticle

Balachandran, S & Barber, GN 2000, 'Vesicular stomatitis virus (VSV) therapy of tumors', IUBMB Life, vol. 50, no. 2, pp. 135-138.
Balachandran, S. ; Barber, Glen N. / Vesicular stomatitis virus (VSV) therapy of tumors. In: IUBMB Life. 2000 ; Vol. 50, No. 2. pp. 135-138.
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