Abstract
Background/Aims: Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cognitive impairment (MCI) is less well known. Methods: Performance on the Controlled Oral Word Association Test (COWAT) and Animal fluency was compared in control, amnestic MCI, non-amnestic MCI, and AD groups. The sample included 136 participants matched for age, education, and gender. Results: Both MCI groups performed similarly with a category > letter fluency pattern rather than a category < letter fluency pattern typically observed in AD. The pattern in MCI, albeit relatively more impaired than in controls, was more similar to healthy controls who exhibited a category > letter fluency pattern. Conclusion: MCI using a category < letter fluency pattern may not represent AD; however, future research requires longitudinal studies of pattern analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 38 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Keywords
- Alzheimer's disease
- Cognitive impairment
- Dementia
- Mild cognitive impairment
- Neuropsychological assessment
- Phonetic fluency
- Semantic fluency
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Cognitive Neuroscience
Cite this
Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease. / Rinehardt, Eric; Eichstaedt, Katie; Schinka, John A.; Loewenstein, David; Mattingly, Michelle; Fils, Jean; Duara, Ranjan; Schoenberg, Mike R.
In: Dementia and Geriatric Cognitive Disorders, Vol. 38, No. 1-2, 01.01.2014, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease
AU - Rinehardt, Eric
AU - Eichstaedt, Katie
AU - Schinka, John A.
AU - Loewenstein, David
AU - Mattingly, Michelle
AU - Fils, Jean
AU - Duara, Ranjan
AU - Schoenberg, Mike R.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background/Aims: Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cognitive impairment (MCI) is less well known. Methods: Performance on the Controlled Oral Word Association Test (COWAT) and Animal fluency was compared in control, amnestic MCI, non-amnestic MCI, and AD groups. The sample included 136 participants matched for age, education, and gender. Results: Both MCI groups performed similarly with a category > letter fluency pattern rather than a category < letter fluency pattern typically observed in AD. The pattern in MCI, albeit relatively more impaired than in controls, was more similar to healthy controls who exhibited a category > letter fluency pattern. Conclusion: MCI using a category < letter fluency pattern may not represent AD; however, future research requires longitudinal studies of pattern analysis.
AB - Background/Aims: Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cognitive impairment (MCI) is less well known. Methods: Performance on the Controlled Oral Word Association Test (COWAT) and Animal fluency was compared in control, amnestic MCI, non-amnestic MCI, and AD groups. The sample included 136 participants matched for age, education, and gender. Results: Both MCI groups performed similarly with a category > letter fluency pattern rather than a category < letter fluency pattern typically observed in AD. The pattern in MCI, albeit relatively more impaired than in controls, was more similar to healthy controls who exhibited a category > letter fluency pattern. Conclusion: MCI using a category < letter fluency pattern may not represent AD; however, future research requires longitudinal studies of pattern analysis.
KW - Alzheimer's disease
KW - Cognitive impairment
KW - Dementia
KW - Mild cognitive impairment
KW - Neuropsychological assessment
KW - Phonetic fluency
KW - Semantic fluency
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UR - http://www.scopus.com/inward/citedby.url?scp=84895653753&partnerID=8YFLogxK
U2 - 10.1159/000355558
DO - 10.1159/000355558
M3 - Article
C2 - 24556750
AN - SCOPUS:84895653753
VL - 38
SP - 1
EP - 9
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 1-2
ER -