Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease

Eric Rinehardt, Katie Eichstaedt, John A. Schinka, David Loewenstein, Michelle Mattingly, Jean Fils, Ranjan Duara, Mike R. Schoenberg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background/Aims: Verbal fluency patterns can assist in differential diagnosis during neuropsychological assessment and identify individuals at risk for developing Alzheimer's disease (AD). While evidence suggests that subjects with AD perform worse on category fluency than letter fluency tasks, the pattern in mild cognitive impairment (MCI) is less well known. Methods: Performance on the Controlled Oral Word Association Test (COWAT) and Animal fluency was compared in control, amnestic MCI, non-amnestic MCI, and AD groups. The sample included 136 participants matched for age, education, and gender. Results: Both MCI groups performed similarly with a category > letter fluency pattern rather than a category < letter fluency pattern typically observed in AD. The pattern in MCI, albeit relatively more impaired than in controls, was more similar to healthy controls who exhibited a category > letter fluency pattern. Conclusion: MCI using a category < letter fluency pattern may not represent AD; however, future research requires longitudinal studies of pattern analysis.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Volume38
Issue number1-2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Alzheimer Disease
Word Association Tests
Longitudinal Studies
Differential Diagnosis
Cognitive Dysfunction
Education

Keywords

  • Alzheimer's disease
  • Cognitive impairment
  • Dementia
  • Mild cognitive impairment
  • Neuropsychological assessment
  • Phonetic fluency
  • Semantic fluency

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

Cite this

Rinehardt, E., Eichstaedt, K., Schinka, J. A., Loewenstein, D., Mattingly, M., Fils, J., ... Schoenberg, M. R. (2014). Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 38(1-2), 1-9. https://doi.org/10.1159/000355558

Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease. / Rinehardt, Eric; Eichstaedt, Katie; Schinka, John A.; Loewenstein, David; Mattingly, Michelle; Fils, Jean; Duara, Ranjan; Schoenberg, Mike R.

In: Dementia and Geriatric Cognitive Disorders, Vol. 38, No. 1-2, 01.01.2014, p. 1-9.

Research output: Contribution to journalArticle

Rinehardt, E, Eichstaedt, K, Schinka, JA, Loewenstein, D, Mattingly, M, Fils, J, Duara, R & Schoenberg, MR 2014, 'Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease', Dementia and Geriatric Cognitive Disorders, vol. 38, no. 1-2, pp. 1-9. https://doi.org/10.1159/000355558
Rinehardt, Eric ; Eichstaedt, Katie ; Schinka, John A. ; Loewenstein, David ; Mattingly, Michelle ; Fils, Jean ; Duara, Ranjan ; Schoenberg, Mike R. / Verbal fluency patterns in mild cognitive impairment and Alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 2014 ; Vol. 38, No. 1-2. pp. 1-9.
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