Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels

Treatment with thrombolysis

Charif Sidani, Walid Ballourah, Mohamad El Dassouki, Samar Muwakkit, Ibrahim Dabbous, Hanan Dahoui, Aghiad Al-Kutoubi, Miguel R. Abboud

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A 21-year-old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This patient however had consistently elevated hemoglobin levels both at the time of the initial event and on follow up. One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient.

Original languageEnglish
Pages (from-to)818-820
Number of pages3
JournalAmerican Journal of Hematology
Volume83
Issue number10
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

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Intracranial Sinus Thrombosis
Hydroxyurea
Sickle Cell Anemia
Venous Thrombosis
Hemoglobins
Stroke
Sigmoid Colon
Hip
Thrombosis
Necrosis
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels : Treatment with thrombolysis. / Sidani, Charif; Ballourah, Walid; El Dassouki, Mohamad; Muwakkit, Samar; Dabbous, Ibrahim; Dahoui, Hanan; Al-Kutoubi, Aghiad; Abboud, Miguel R.

In: American Journal of Hematology, Vol. 83, No. 10, 01.10.2008, p. 818-820.

Research output: Contribution to journalArticle

Sidani, Charif ; Ballourah, Walid ; El Dassouki, Mohamad ; Muwakkit, Samar ; Dabbous, Ibrahim ; Dahoui, Hanan ; Al-Kutoubi, Aghiad ; Abboud, Miguel R. / Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels : Treatment with thrombolysis. In: American Journal of Hematology. 2008 ; Vol. 83, No. 10. pp. 818-820.
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