Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels: Treatment with thrombolysis

Charit A. Sidani, Walid Ballourah, Mohamad El Dassouki, Samar Muwakkit, Ibrahim Dabbous, Hanan Dahoui, Aghiad Al-Kutoubi, Miguel R. Abboud

Research output: Contribution to journalArticle

24 Scopus citations


A 21-year-old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This patient however had consistently elevated hemoglobin levels both at the time of the initial event and on follow up. One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient.

Original languageEnglish (US)
Pages (from-to)818-820
Number of pages3
JournalAmerican Journal of Hematology
Issue number10
StatePublished - Oct 1 2008
Externally publishedYes


ASJC Scopus subject areas

  • Hematology

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