Velimogene aliplasmid

Heloisa P. Soares, Jose Lutzky

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Importance of the field: Immunotherapy for cancer has been investigated for several decades, achieving limited success. The development of effective new immunotherapeutic agents has reignited interest in the filed. Intralesional injection of plasmids in order to transfect genes capable of stimulating or augmenting immune recognition and destruction of tumors is a relatively new approach. Areas covered in this review: Our objective is to discuss the role velimogene aliplasmid (Allovectin-7®, Vical Incorporated), a plasmidlipid complex containing the DNA sequences encoding HLA-B7 and β2 microglobulin, as an immunotherapeutic agent. What the reader will gain: Intralesional velimogene aliplasmid induces anti-tumor responses in a proportion of melanoma patients with locoregional and limited distant metastases. Preclinical data and the results of Phase I, II and III clinical trials with this drug are reviewed. The limited data in other malignancies is also reviewed. Velimogene aliplasmid in humans appears safe, with minimal drug-related adverse events. Take home message: Velimogene aliplasmid has activity in melanoma with local and limited distant disease associated with an excellent safety profile. The activity of this approach is also being investigated in other malignancies.

Original languageEnglish (US)
Pages (from-to)841-851
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume10
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Allovectin
  • Immunotherapy
  • Melanoma
  • Vaccines
  • Velimogene aliplasmid

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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