Vein Involvement During Pancreaticoduodenectomy: Is There a Need for Redefinition of "Borderline Resectable Disease"?

Kaitlyn J. Kelly, Emily Winslow, David Kooby, Neha L. Lad, Alexander A. Parikh, Charles R. Scoggins, Syed Ahmad, Robert C. Martin, Shishir K. Maithel, H. J. Kim, Nipun B. Merchant, Clifford S. Cho, Sharon M. Weber

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Introduction: Current National Comprehensive Cancer Network guidelines recommend neoadjuvant therapy for borderline resectable pancreatic adenocarcinoma to increase the likelihood of achieving R0 resection. A consensus has not been reached on the degree of venous involvement that constitutes borderline resectability. This study compares the outcome of patients who underwent pancreaticoduodenectomy with or without vein resection without neoadjuvant therapy. Methods: A multi-institutional database of patients who underwent pancreaticoduodenectomy was reviewed. Patients who required vein resection due to gross vein involvement by tumor were compared to those without evidence of vein involvement. Results: Of 492 patients undergoing pancreaticoduodenectomy, 70 (14 %) had vein resection and 422 (86 %) did not. There was no difference in R0 resection (66 vs. 75 %, p = NS). On multivariate analysis, vein involvement was not predictive of disease-free or overall survival. Conclusion: This is the largest modern series examining patients with or without isolated vein involvement by pancreas cancer, none of whom received neoadjuvant therapy. Oncological outcome was not different between the two groups. These data suggest that up-front surgical resection is an appropriate option and call into question the inclusion of isolated vein involvement in the definition of "borderline resectable disease."

Original languageEnglish (US)
Pages (from-to)1209-1217
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume17
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Borderline resectable pancreas cancer
  • Pancreatic adenocarcinoma
  • Pancreaticoduodenectomy
  • Vein involvement

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Fingerprint

Dive into the research topics of 'Vein Involvement During Pancreaticoduodenectomy: Is There a Need for Redefinition of "Borderline Resectable Disease"?'. Together they form a unique fingerprint.

Cite this