Vasomotion influences airflow in peripheral airways

M. E. Csete, W. M. Abraham, Adam Wanner

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The purpose of this study was to test the hypothesis that blood flow, by its effect on blood volume, influences airflow resistance in peripheral airways. In conscious ewes, forced sinusoidal flow oscillations (5 Hz) were applied through a balloon-tipped, dual-channel fiberoptic bronchoscope placed in a segmental bronchus, and peripheral airflow resistance (R(p)) was determined from flow and bronchial pressure. Drugs with predominant vascular or airway smooth muscle effects were administered locally through the bronchoscope. Nitroglycerin (NTG) produced a dose-dependent increase in mean R(p) (+288% at 1,000 μg), which was blocked by methylene blue (p<0.05) and not reversed by atropine. Carbachol (CARB) also increased mean R(p) in a dose-dependent manner (+605% at 400 μg); this effect was not blocked by methylene blue, but it was reversed by atropine (p<0.05). The increase in mean R(p) after a single dose of NTG (250 μg) was sustained for at least 20 min and transiently reversed by vasopressin (0.2 units, p<0.05) but not by isoproterenol (100 μg). Conversely, the sustained increase in R(p) after a single dose of CARB (50 μg) was transiently reversed by isoproterenol (p<0.05) but not by vasopressin. We conclude that NTG increased R(p) by vasodilation and CARB by bronchoconstriction. This supports the hypothesis that vasodilation limits airflow in the lung periphery, presumably because of vascular congestion.

Original languageEnglish
Pages (from-to)1409-1413
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume141
Issue number6
StatePublished - Jan 1 1990

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Nitroglycerin
Carbachol
Bronchoscopes
Methylene Blue
Vasopressins
Atropine
Isoproterenol
Vasodilation
Vascular Resistance
Blood Vessels
Bronchoconstriction
Hematologic Tests
Bronchi
Blood Volume
Smooth Muscle
Pressure
Lung
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Vasomotion influences airflow in peripheral airways. / Csete, M. E.; Abraham, W. M.; Wanner, Adam.

In: American Review of Respiratory Disease, Vol. 141, No. 6, 01.01.1990, p. 1409-1413.

Research output: Contribution to journalArticle

Csete, M. E. ; Abraham, W. M. ; Wanner, Adam. / Vasomotion influences airflow in peripheral airways. In: American Review of Respiratory Disease. 1990 ; Vol. 141, No. 6. pp. 1409-1413.
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