Vasodilator actions of Interleukin-1 in the canine coronary circulation

D. Kenny, G. Mc Carthy-Kenny, L. R. Pele, H. S. Cheung, H. L. Brooks, D. C. Warltier

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effects of intracoronary ultrapure human Interleukin-1 on the regional distribution of coronary blood flow (radioactive microspheres), contractile function (subendocardial ultrasonic length gauges) and systemic hemodynamics were studied in open-chest, anesthetized dogs (n=7). Bolus doses of Interleukin-1 (10, 20, and 30 u) administered directly into the left anterior descending coronary artery increased coronary blood flow from 43 to 71, 80 and 87 ml/min, respectively. The increase in blood flow produced by Interleukin-1 was distributed uniformly to the subendocardium, midmyocardium, and subepicardium of the left ventricular free wall without effect on regional function or systemic hemodynamics. Indomethacin (1 mg/kg i.v.) attenuated the increase in blood flow, especially to the subepicardium. Due to the selective diminution of the Interleukin-1-mediated increase in subepicardial blood flow by indomethacin, the subendocardial to subepicardial perfusion ratio was increased by Interleukin-1 in the presence of indomethacin. The present results demonstrate that Interleukin-1 has direct coronary vasodilator actions, a portion of which is mediated by a product of cyclooxygenase metabolism.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalBasic Research in Cardiology
Volume85
Issue number3
DOIs
StatePublished - May 1990
Externally publishedYes

Keywords

  • coronary circulation
  • coronary vasodilation
  • Interleukin-1
  • regional myocardial blood flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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