Vascular Smooth Muscle Cells in Cerebral Aneurysm Pathogenesis

Robert M. Starke, Nohra Chalouhi, Dale Ding, Daniel M.S. Raper, M. Sean Mckisic, Gary K. Owens, David M. Hasan, Ricky Medel, Aaron S. Dumont

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Vascular smooth muscle cells (SMC) maintain significant plasticity. Following environmental stimulation, SMC can alter their phenotype from one primarily concerned with contraction to a pro-inflammatory and matrix remodeling phenotype. This is a critical process behind peripheral vascular disease and atherosclerosis, a key element of cerebral aneurysm pathology. Evolving evidence demonstrates that SMCs and phenotypic modulation play a significant role in cerebral aneurysm formation and rupture. Pharmacological alteration of smooth muscle cell function and phenotypic modulation could provide a promising medical therapy to inhibit cerebral aneurysm progression. This study reviews vascular SMC function and its contribution to cerebral aneurysm pathophysiology.

Original languageEnglish (US)
Pages (from-to)338-346
Number of pages9
JournalTranslational stroke research
Volume5
Issue number3
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Aneurysm
  • Cells
  • Inflammation
  • Smooth muscle
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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