Vascular malformation with radiation vasculopathy after treatment of chiasmatic/hypothalamic glioma

M. A. Epstein, R. J. Packer, L. B. Rorke, R. A. Zimmerman, J. W. Goldwein, L. N. Sutton, L. Schut

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Chiasmatic/hypothalamic gliomas usually are histologically benign astrocytomas that may recur many years after diagnosis and treatment. Three children with chiasmatic/hypothalamic gliomas who were treated at the authors' institution returned 9.5, 11.5, and 2 years, respectively, after radiation therapy (RT) because visual and neurologic deterioration developed. Neuroradiographic studies, including arteriography in two of the patients, showed large mass lesions. These were presumed to be recurrence of tumor, and chemotherapy was administered. Pathologic examination of two children who died and of the third who had a biopsy revealed only a minimal amount of residual, histologically benign astrocytoma, whereas the bulk of the specimen consisted of numerous vessels of variable size. These probably represented incorporation of the rich vasculature in the chiasmal region into the tumor, which underwent degeneration secondary to RT. Radiographic methods did not distinguish progressive tumor growth from the vasculopathy and led to inappropriate clinical diagnoses and treatment.

Original languageEnglish
Pages (from-to)887-893
Number of pages7
Issue number4
StatePublished - Aug 20 1992


  • chiasmatic/hypothalamic glioma
  • radiation vasculopathy
  • vascular degeneration
  • vascular malformation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Vascular malformation with radiation vasculopathy after treatment of chiasmatic/hypothalamic glioma'. Together they form a unique fingerprint.

Cite this