Vascular actions of hypothermia in brain trauma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Traumatic brain injury (TBI) is a serious condition that affects approximately 1.5 million people in the United States each year. Currently, there are no approved therapies to treat the devastating consequences of severe TBI. Therapeutic hypothermia has a history of showing efficacy both in animal models and clinical studies. Potential mechanisms by which hypothermia may improve traumatic outcome include targeting vascular alterations such as by reducing the incidence of blood-brain barrier (BBB) permeability. In addition, therapeutic hypothermia promotes normal vascular reactivity and reduces a variety of inflammatory processes that are activated by trauma-induced cerebrovascular damage. Ongoing research in the laboratory and clinic is demonstrating that therapeutic hypothermia may indeed protect specific populations of severe TBI patients by targeting vascular perturbations including altered BBB function.

Original languageEnglish (US)
Title of host publicationVascular Mechanisms in CNS Trauma
PublisherSpringer New York
Pages223-235
Number of pages13
ISBN (Electronic)9781461486909
ISBN (Print)9781461486893
DOIs
StatePublished - Jan 1 2014

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Induced Hypothermia
Hypothermia
Blood Vessels
Blood-Brain Barrier
Cerebrovascular Trauma
Permeability
Animal Models
Incidence
Research
Population
Traumatic Brain Injury
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Vascular actions of hypothermia in brain trauma. / Dalton Dietrich, W.; Bramlett, Helen.

Vascular Mechanisms in CNS Trauma. Springer New York, 2014. p. 223-235.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dalton Dietrich, W. ; Bramlett, Helen. / Vascular actions of hypothermia in brain trauma. Vascular Mechanisms in CNS Trauma. Springer New York, 2014. pp. 223-235
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