Varicella-zoster virus leukoencephalitis and cerebral vasculopathy

S. Morgello, G. A. Block, R. W. Price, Carol Petito

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Two patients with varicella-zoster virus leukoencephalitis and acquired immunodeficiency syndrome are described. Neither patient had cutaneous or disseminated varicella-zoster virus infection within the last six months of life. Demyelinated lesions resembling those of progressive multifocal leukoencephalopathy were seen in their brains at autopsy. Numerous cells with Cowdry type A intranuclear inclusions surrounded the lesions; these cells stained positively for varicella-zoster virus with immunohistochemistry and contained herpesvirus nucleocapsids by electron microscopy. Leptomeningeal vessels accompanying the lesions displayed a zoster-induced vasculopathy in one of the two patients. Vascular and parenchymal central nervous system infections with varicella-zoster virus are rare in the absence of cutaneous lesions, and to our knowledge, the presence of both in one patient has not yet been described.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume112
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

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Human Herpesvirus 3
Progressive Multifocal Leukoencephalopathy
Intranuclear Inclusion Bodies
Central Nervous System Infections
Nucleocapsid
Skin
Herpesviridae
Herpes Zoster
Virus Diseases
Blood Vessels
Autopsy
Electron Microscopy
Acquired Immunodeficiency Syndrome
Immunohistochemistry
Brain

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Morgello, S., Block, G. A., Price, R. W., & Petito, C. (1988). Varicella-zoster virus leukoencephalitis and cerebral vasculopathy. Archives of Pathology and Laboratory Medicine, 112(2), 173-177.

Varicella-zoster virus leukoencephalitis and cerebral vasculopathy. / Morgello, S.; Block, G. A.; Price, R. W.; Petito, Carol.

In: Archives of Pathology and Laboratory Medicine, Vol. 112, No. 2, 01.01.1988, p. 173-177.

Research output: Contribution to journalArticle

Morgello, S, Block, GA, Price, RW & Petito, C 1988, 'Varicella-zoster virus leukoencephalitis and cerebral vasculopathy', Archives of Pathology and Laboratory Medicine, vol. 112, no. 2, pp. 173-177.
Morgello, S. ; Block, G. A. ; Price, R. W. ; Petito, Carol. / Varicella-zoster virus leukoencephalitis and cerebral vasculopathy. In: Archives of Pathology and Laboratory Medicine. 1988 ; Vol. 112, No. 2. pp. 173-177.
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