Variations in normal serum alpha-fetoprotein (AFP) levels in patients with testicular cancer on surveillance

Priti Patel, Raymond Balise, Sandy Srinivas

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: The aim of this study was to assess fluctuations in normal serum alpha-fetoprotein (AFP) levels in patients with germ cell cancer. Marked variations occur after serum AFP levels normalize, creating anxiety among patients and physicians during surveillance. Patients and Methods: We conducted a retrospective review of patients with germ cell tumors in clinical remission, who had normal AFP levels and were followed at our center from 1991 to 2009. 72 patients, with a median follow-up of 50 months, were identified. Results: Of the 72 patients, 57 (79%) had a non-seminomatous germ cell histology, and 15 (21%) had seminomas. Seminomas were included as controls as serum AFP levels do not increase in this group. 68 patients underwent orchiectomy, and 50 patients received systemic chemotherapy. The majority of patients (93%) demonstrated fluctuations in serum AFP. There was no difference in the mean AFP values between patients with seminona (2.95 ng/ml) and those with non-seminomatous germ cell tumors (3.3 ng/ml) (standard deviation 1.01 ng/ml). Conclusion: Marked variations occur after serum AFP levels normalize in patients undergoing surveillance. Fluctuating AFP levels within normal limits did not result in relapse in our cohort of patients with extended follow-up.

Original languageEnglish (US)
Pages (from-to)588-591
Number of pages4
JournalOnkologie
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Keywords

  • Chemotherapy
  • Relapse
  • Serum AFP
  • Surveillance

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Variations in normal serum alpha-fetoprotein (AFP) levels in patients with testicular cancer on surveillance'. Together they form a unique fingerprint.

  • Cite this