Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

Amanda J Myers, Helen Marshall, Peter Holmans, Danielle Compton, Richard J P Crook, Adrian P. Mander, Petra Nowotny, Scott Smemo, Melanie Dunstan, Luke Jehu, Jen C. Wang, Marian Hamshere, John C. Morris, Joanne Norton, Sumi Chakraventy, Nigel Tunstall, Simon Lovestone, Ronald Petersen, Michael O'Donovan, Lesley Jones & 4 others Julie Williams, Michael J. Owen, John Hardy, Alison Goate

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume124 B
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 10
Plasminogen Activators
Urokinase-Type Plasminogen Activator
Information Storage and Retrieval
Genes
Alzheimer Disease

Keywords

  • Alzheimer disease
  • Association study
  • Candidate gene
  • PLAU
  • Urokinase-plasminogen activator

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD. / Myers, Amanda J; Marshall, Helen; Holmans, Peter; Compton, Danielle; Crook, Richard J P; Mander, Adrian P.; Nowotny, Petra; Smemo, Scott; Dunstan, Melanie; Jehu, Luke; Wang, Jen C.; Hamshere, Marian; Morris, John C.; Norton, Joanne; Chakraventy, Sumi; Tunstall, Nigel; Lovestone, Simon; Petersen, Ronald; O'Donovan, Michael; Jones, Lesley; Williams, Julie; Owen, Michael J.; Hardy, John; Goate, Alison.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 124 B, No. 1, 01.01.2004, p. 29-37.

Research output: Contribution to journalArticle

Myers, AJ, Marshall, H, Holmans, P, Compton, D, Crook, RJP, Mander, AP, Nowotny, P, Smemo, S, Dunstan, M, Jehu, L, Wang, JC, Hamshere, M, Morris, JC, Norton, J, Chakraventy, S, Tunstall, N, Lovestone, S, Petersen, R, O'Donovan, M, Jones, L, Williams, J, Owen, MJ, Hardy, J & Goate, A 2004, 'Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 124 B, no. 1, pp. 29-37.
Myers, Amanda J ; Marshall, Helen ; Holmans, Peter ; Compton, Danielle ; Crook, Richard J P ; Mander, Adrian P. ; Nowotny, Petra ; Smemo, Scott ; Dunstan, Melanie ; Jehu, Luke ; Wang, Jen C. ; Hamshere, Marian ; Morris, John C. ; Norton, Joanne ; Chakraventy, Sumi ; Tunstall, Nigel ; Lovestone, Simon ; Petersen, Ronald ; O'Donovan, Michael ; Jones, Lesley ; Williams, Julie ; Owen, Michael J. ; Hardy, John ; Goate, Alison. / Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2004 ; Vol. 124 B, No. 1. pp. 29-37.
@article{870ce2fcfa334479a4a79e97a977f079,
title = "Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD",
abstract = "Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.",
keywords = "Alzheimer disease, Association study, Candidate gene, PLAU, Urokinase-plasminogen activator",
author = "Myers, {Amanda J} and Helen Marshall and Peter Holmans and Danielle Compton and Crook, {Richard J P} and Mander, {Adrian P.} and Petra Nowotny and Scott Smemo and Melanie Dunstan and Luke Jehu and Wang, {Jen C.} and Marian Hamshere and Morris, {John C.} and Joanne Norton and Sumi Chakraventy and Nigel Tunstall and Simon Lovestone and Ronald Petersen and Michael O'Donovan and Lesley Jones and Julie Williams and Owen, {Michael J.} and John Hardy and Alison Goate",
year = "2004",
month = "1",
day = "1",
language = "English",
volume = "124 B",
pages = "29--37",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Variation in the Urokinase-Plasminogen Activator Gene Does Not Explain the Chromosome 10 Linkage Signal for Late Onset AD

AU - Myers, Amanda J

AU - Marshall, Helen

AU - Holmans, Peter

AU - Compton, Danielle

AU - Crook, Richard J P

AU - Mander, Adrian P.

AU - Nowotny, Petra

AU - Smemo, Scott

AU - Dunstan, Melanie

AU - Jehu, Luke

AU - Wang, Jen C.

AU - Hamshere, Marian

AU - Morris, John C.

AU - Norton, Joanne

AU - Chakraventy, Sumi

AU - Tunstall, Nigel

AU - Lovestone, Simon

AU - Petersen, Ronald

AU - O'Donovan, Michael

AU - Jones, Lesley

AU - Williams, Julie

AU - Owen, Michael J.

AU - Hardy, John

AU - Goate, Alison

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

AB - Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Aβ42 levels suggesting that a single locus may influence risk for AD by elevating plasma Aβ42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

KW - Alzheimer disease

KW - Association study

KW - Candidate gene

KW - PLAU

KW - Urokinase-plasminogen activator

UR - http://www.scopus.com/inward/record.url?scp=0346102515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346102515&partnerID=8YFLogxK

M3 - Article

VL - 124 B

SP - 29

EP - 37

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 1

ER -