Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography

Christopher A. Girkin, Gerald McGwin, Micheal J. Sinai, G. Chandra Sekhar, Murrey Fingeret, Gadi Wollstein, Rohit Varma, David Greenfield, Jeffery Liebmann, Makoto Araie, Goji Tomita, Naoyuki Maeda, David F. Garway-Heath

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design: Cross-sectional observational study. Participants: Three hundred fifty adult subjects without ocular disease. Methods: Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Main Outcome Measures: Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. Results: For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups (P<0.0001), and Indian participants had significantly smaller rim area than other groups (P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups (P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula (P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm 2/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year (P<0.0001 for all age associations). Conclusions: Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups.

Original languageEnglish
Pages (from-to)2403-2408
Number of pages6
JournalOphthalmology
Volume118
Issue number12
DOIs
StatePublished - Dec 1 2011

Fingerprint

Optical Coherence Tomography
Optic Nerve
Nerve Fibers
Optic Disk
Eye Diseases
Optic Nerve Diseases
Population Groups
Hispanic Americans
Observational Studies
Reference Values
Age Groups
Cross-Sectional Studies
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Girkin, C. A., McGwin, G., Sinai, M. J., Sekhar, G. C., Fingeret, M., Wollstein, G., ... Garway-Heath, D. F. (2011). Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography. Ophthalmology, 118(12), 2403-2408. https://doi.org/10.1016/j.ophtha.2011.06.013

Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography. / Girkin, Christopher A.; McGwin, Gerald; Sinai, Micheal J.; Sekhar, G. Chandra; Fingeret, Murrey; Wollstein, Gadi; Varma, Rohit; Greenfield, David; Liebmann, Jeffery; Araie, Makoto; Tomita, Goji; Maeda, Naoyuki; Garway-Heath, David F.

In: Ophthalmology, Vol. 118, No. 12, 01.12.2011, p. 2403-2408.

Research output: Contribution to journalArticle

Girkin, CA, McGwin, G, Sinai, MJ, Sekhar, GC, Fingeret, M, Wollstein, G, Varma, R, Greenfield, D, Liebmann, J, Araie, M, Tomita, G, Maeda, N & Garway-Heath, DF 2011, 'Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography', Ophthalmology, vol. 118, no. 12, pp. 2403-2408. https://doi.org/10.1016/j.ophtha.2011.06.013
Girkin, Christopher A. ; McGwin, Gerald ; Sinai, Micheal J. ; Sekhar, G. Chandra ; Fingeret, Murrey ; Wollstein, Gadi ; Varma, Rohit ; Greenfield, David ; Liebmann, Jeffery ; Araie, Makoto ; Tomita, Goji ; Maeda, Naoyuki ; Garway-Heath, David F. / Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography. In: Ophthalmology. 2011 ; Vol. 118, No. 12. pp. 2403-2408.
@article{8a4f51173ca1485b9bb31725351d4573,
title = "Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography",
abstract = "Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design: Cross-sectional observational study. Participants: Three hundred fifty adult subjects without ocular disease. Methods: Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Main Outcome Measures: Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. Results: For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups (P<0.0001), and Indian participants had significantly smaller rim area than other groups (P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups (P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula (P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm 2/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year (P<0.0001 for all age associations). Conclusions: Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups.",
author = "Girkin, {Christopher A.} and Gerald McGwin and Sinai, {Micheal J.} and Sekhar, {G. Chandra} and Murrey Fingeret and Gadi Wollstein and Rohit Varma and David Greenfield and Jeffery Liebmann and Makoto Araie and Goji Tomita and Naoyuki Maeda and Garway-Heath, {David F.}",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.ophtha.2011.06.013",
language = "English",
volume = "118",
pages = "2403--2408",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography

AU - Girkin, Christopher A.

AU - McGwin, Gerald

AU - Sinai, Micheal J.

AU - Sekhar, G. Chandra

AU - Fingeret, Murrey

AU - Wollstein, Gadi

AU - Varma, Rohit

AU - Greenfield, David

AU - Liebmann, Jeffery

AU - Araie, Makoto

AU - Tomita, Goji

AU - Maeda, Naoyuki

AU - Garway-Heath, David F.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design: Cross-sectional observational study. Participants: Three hundred fifty adult subjects without ocular disease. Methods: Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Main Outcome Measures: Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. Results: For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups (P<0.0001), and Indian participants had significantly smaller rim area than other groups (P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups (P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula (P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm 2/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year (P<0.0001 for all age associations). Conclusions: Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups.

AB - Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design: Cross-sectional observational study. Participants: Three hundred fifty adult subjects without ocular disease. Methods: Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Main Outcome Measures: Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. Results: For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups (P<0.0001), and Indian participants had significantly smaller rim area than other groups (P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups (P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula (P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm 2/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year (P<0.0001 for all age associations). Conclusions: Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups.

UR - http://www.scopus.com/inward/record.url?scp=82755182693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82755182693&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2011.06.013

DO - 10.1016/j.ophtha.2011.06.013

M3 - Article

C2 - 21907415

AN - SCOPUS:82755182693

VL - 118

SP - 2403

EP - 2408

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 12

ER -