Variability of manual ciliary muscle segmentation in optical coherence tomography images

Yu Cherng Chang, Keke Liu, Florence Cabot, Sonia H. Yoo, Marco Ruggeri, Arthur Ho, Jean Marie Parel, Fabrice Manns

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Optical coherence tomography (OCT) offers new options for imaging the ciliary muscle allowing direct in vivo visualization. However, variation in image quality along the length of the muscle prevents accurate delineation and quantification of the muscle. Quantitative analyses of the muscle are accompanied by variability in segmentation between examiners and between sessions for the same examiner. In processes such as accommodation where changes in muscle thickness may be tens of microns- the equivalent of a small number of image pixels, differences in segmentation can influence the magnitude and potentially the direction of thickness change. A detailed analysis of variability in ciliary muscle thickness measurements was performed to serve as a benchmark for the extent of this variability in studies on the ciliary muscle. Variation between sessions and examiners were found to be insignificant but the magnitude of variation should be considered when interpreting ciliary muscle results.

Original languageEnglish (US)
Article number#313988
Pages (from-to)791-800
Number of pages10
JournalBiomedical Optics Express
Issue number2
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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