Variability in clinical target volume delineation for intensity modulated radiation therapy in 3 challenging cervix cancer scenarios

Karen Lim, Beth Erickson, Ina M. Jürgenliemk-Schulz, David Gaffney, Carien L. Creutzberg, Akila Viswanathan, Lorraine Portelance, Sushil Beriwal, Aaron Wolfson, Walter Bosch, Jennifer De Los Santos, Catheryn Yashar, Anuja Jhingran, Mahesh Varia, Issam El Naqa, Bronwyn King, Anthony Fyles

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to assess variability in contouring the gross tumor volume (GTV) and clinical target volume (CTV) of 3 clinical cervix cancer cases by a cohort of international experts in the field in preparation for the development of an online teaching atlas. Methods and materials: Twelve international experts participated. Three clinical scenarios: node positivity (PLN), retroverted uterus (RV), and parametrial invasion (PI) were used. Sagittal and axial magnetic resonance images of the clinical cases were downloaded to participants' treatment planning systems for contouring. The GTV/cervix/uterus/parametria/vagina and nodal CTV were contoured. Contour consensus was assessed for sensitivity/specificity using an expectation maximization algorithm called Simultaneous Truth and Performance Level Estimation and experts' overall agreement was summarized by kappa statistics. Results: Agreement for GTV in the 3 clinical cases was high (Simultaneous Truth and Performance Level Estimation sensitivity, 0.54-0.92; specificity, 0.97-0.98; and kappa measure for PLN, RV, and PI was 0.86, 0.76, and 0.42; P

Original languageEnglish (US)
Pages (from-to)e557-e565
JournalPractical Radiation Oncology
Volume5
Issue number6
DOIs
StatePublished - Nov 1 2015

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Uterine Retroversion
Tumor Burden
Uterine Cervical Neoplasms
Radiotherapy
Atlases
Peritoneum
Vagina
Cervix Uteri
Teaching
Magnetic Resonance Spectroscopy
Sensitivity and Specificity
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Lim, K., Erickson, B., Jürgenliemk-Schulz, I. M., Gaffney, D., Creutzberg, C. L., Viswanathan, A., ... Fyles, A. (2015). Variability in clinical target volume delineation for intensity modulated radiation therapy in 3 challenging cervix cancer scenarios. Practical Radiation Oncology, 5(6), e557-e565. https://doi.org/10.1016/j.prro.2015.06.011

Variability in clinical target volume delineation for intensity modulated radiation therapy in 3 challenging cervix cancer scenarios. / Lim, Karen; Erickson, Beth; Jürgenliemk-Schulz, Ina M.; Gaffney, David; Creutzberg, Carien L.; Viswanathan, Akila; Portelance, Lorraine; Beriwal, Sushil; Wolfson, Aaron; Bosch, Walter; De Los Santos, Jennifer; Yashar, Catheryn; Jhingran, Anuja; Varia, Mahesh; El Naqa, Issam; King, Bronwyn; Fyles, Anthony.

In: Practical Radiation Oncology, Vol. 5, No. 6, 01.11.2015, p. e557-e565.

Research output: Contribution to journalArticle

Lim, K, Erickson, B, Jürgenliemk-Schulz, IM, Gaffney, D, Creutzberg, CL, Viswanathan, A, Portelance, L, Beriwal, S, Wolfson, A, Bosch, W, De Los Santos, J, Yashar, C, Jhingran, A, Varia, M, El Naqa, I, King, B & Fyles, A 2015, 'Variability in clinical target volume delineation for intensity modulated radiation therapy in 3 challenging cervix cancer scenarios', Practical Radiation Oncology, vol. 5, no. 6, pp. e557-e565. https://doi.org/10.1016/j.prro.2015.06.011
Lim, Karen ; Erickson, Beth ; Jürgenliemk-Schulz, Ina M. ; Gaffney, David ; Creutzberg, Carien L. ; Viswanathan, Akila ; Portelance, Lorraine ; Beriwal, Sushil ; Wolfson, Aaron ; Bosch, Walter ; De Los Santos, Jennifer ; Yashar, Catheryn ; Jhingran, Anuja ; Varia, Mahesh ; El Naqa, Issam ; King, Bronwyn ; Fyles, Anthony. / Variability in clinical target volume delineation for intensity modulated radiation therapy in 3 challenging cervix cancer scenarios. In: Practical Radiation Oncology. 2015 ; Vol. 5, No. 6. pp. e557-e565.
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