Vancomycin-resistant Gram-positive bacterial endophthalmitis: Epidemiology, treatment options, and outcomes

Manav Khera, Avinash Pathengay, Animesh Jindal, Subhadra Jalali, Annie Mathai, Rajeev Reddy Pappuru, Nidhi Relhan, Taraprasad Das, Savitri Sharma, Harry W. Flynn

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background: The purpose of this study is to evaluate the microbiological profile and treatment outcomes of vancomycin-resistant Gram-positive bacterial endophthalmitis. Medical records of all patients with Gram-positive bacterial endophthalmitis resistant to vancomycin presenting between 1 January 2005 and 31 December 2010 were reviewed in this noncomparative, consecutive, retrospective case series. Favorable outcome was defined as a best-corrected visual acuity of ≥20/200. Results: Out of 682 culture-positive endophthalmitis isolates, 448/682 (65.6%) were associated with Gram-positive bacteria. In vitro resistance to vancomycin was noted in 7/448 (1.56%). Three cases were posttraumatic, three were postoperative, and one was endogenous in origin. Four Bacillus isolates, two Staphylococcus isolates, and an Enterococcus isolate were resistant. Isolates resistant to vancomycin were sensitive in vitro to ciprofloxacin in 6/7 (86%) patients. Presenting visual acuity was light perception in all seven cases. Favorable outcome was achieved in only 1/7 (14.3%) cases. Conclusions: Vancomycin-resistant endophthalmitis is uncommon and usually associated with poor visual outcome. Bacillus sp. is the most frequent Gram-positive bacteria resistant to vancomycin. Fluoroquinolones like ciprofloxacin may be considered as a useful alternative in vancomycin-resistant endophthalmitis.

Original languageEnglish (US)
Article number46
Pages (from-to)1-4
Number of pages4
JournalJournal of Ophthalmic Inflammation and Infection
Issue number1
StatePublished - 2013


  • Antibiotic resistance
  • Antibiotics
  • Endophthalmitis
  • Gram-positive organisms
  • Vancomycin
  • Vitrectomy

ASJC Scopus subject areas

  • Ophthalmology
  • Infectious Diseases


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