Vancomycin-resistant enterococci: 15 years and counting

L. S. Chavers; S. A. Moser; W. H. Benjamin; S. E. Banks; J. R. Steinhauer; A. M. Smith; C. N. Johnson; E. Funkhouser; L. P. Chavers; A. M. Stamm; Ken B. Waites

doi:10.1053/jhin.2002.1375

Vancomycin-resistant enterococci: 15 years and counting

L. S. Chavers, S. A. Moser, W. H. Benjamin, S. E. Banks, J. R. Steinhauer, A. M. Smith, C. N. Johnson, E. Funkhouser, L. P. Chavers, A. M. Stamm, Ken B. Waites

Research output: Contribution to journal › Review article

91 Scopus citations

Abstract

We review the history of vancomycin-resistant enterococci (VRE) and propose a causal model illustrating the roles of exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and prevalence of VRE in the progression from potential VRE reservoirs to active disease in hospitalized patients. Differences in VRE colonization and VRE infection are discussed with respect to hospital surveillance methodology and implications for interventions. We further document clonal transmission of VRE in a large, urban, teaching hospital and demonstrate VRE susceptibility to a wide array of antimicrobial agents. This model can guide the identification of mutable factors that are focal points for intervention.

Original language	English (US)
Pages (from-to)	159-171
Number of pages	13
Journal	Journal of Hospital Infection
Volume	53
Issue number	3
DOIs	https://doi.org/10.1053/jhin.2002.1375
State	Published - Mar 1 2003
Externally published	Yes

Keywords

Antimicrobials
Enterococci
Resistance
Vancomycin

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

Access to Document

10.1053/jhin.2002.1375

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Chavers, L. S., Moser, S. A., Benjamin, W. H., Banks, S. E., Steinhauer, J. R., Smith, A. M., Johnson, C. N., Funkhouser, E., Chavers, L. P., Stamm, A. M., & Waites, K. B. (2003). Vancomycin-resistant enterococci: 15 years and counting. Journal of Hospital Infection, 53(3), 159-171. https://doi.org/10.1053/jhin.2002.1375

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abstract = "We review the history of vancomycin-resistant enterococci (VRE) and propose a causal model illustrating the roles of exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and prevalence of VRE in the progression from potential VRE reservoirs to active disease in hospitalized patients. Differences in VRE colonization and VRE infection are discussed with respect to hospital surveillance methodology and implications for interventions. We further document clonal transmission of VRE in a large, urban, teaching hospital and demonstrate VRE susceptibility to a wide array of antimicrobial agents. This model can guide the identification of mutable factors that are focal points for intervention.",

keywords = "Antimicrobials, Enterococci, Resistance, Vancomycin",

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AU - Chavers, L. S.

AU - Moser, S. A.

AU - Benjamin, W. H.

AU - Banks, S. E.

AU - Steinhauer, J. R.

AU - Smith, A. M.

AU - Johnson, C. N.

AU - Funkhouser, E.

AU - Chavers, L. P.

AU - Stamm, A. M.

AU - Waites, Ken B.

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