Vancomycin-resistant enterococci: 15 years and counting

L. S. Chavers; S. A. Moser; W. H. Benjamin; S. E. Banks; J. R. Steinhauer; A. M. Smith; C. N. Johnson; E. Funkhouser; L. P. Chavers; A. M. Stamm; Ken B. Waites

doi:10.1053/jhin.2002.1375

Vancomycin-resistant enterococci: 15 years and counting

L. S. Chavers, S. A. Moser, W. H. Benjamin, S. E. Banks, J. R. Steinhauer, A. M. Smith, C. N. Johnson, E. Funkhouser, L. P. Chavers, A. M. Stamm, Ken B. Waites

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

We review the history of vancomycin-resistant enterococci (VRE) and propose a causal model illustrating the roles of exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and prevalence of VRE in the progression from potential VRE reservoirs to active disease in hospitalized patients. Differences in VRE colonization and VRE infection are discussed with respect to hospital surveillance methodology and implications for interventions. We further document clonal transmission of VRE in a large, urban, teaching hospital and demonstrate VRE susceptibility to a wide array of antimicrobial agents. This model can guide the identification of mutable factors that are focal points for intervention.

Original language	English (US)
Pages (from-to)	159-171
Number of pages	13
Journal	Journal of Hospital Infection
Volume	53
Issue number	3
DOIs	https://doi.org/10.1053/jhin.2002.1375
State	Published - Mar 2003
Externally published	Yes

Keywords

Antimicrobials
Enterococci
Resistance
Vancomycin

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

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10.1053/jhin.2002.1375

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Vancomycin-resistant enterococci : 15 years and counting. / Chavers, L. S.; Moser, S. A.; Benjamin, W. H.; Banks, S. E.; Steinhauer, J. R.; Smith, A. M.; Johnson, C. N.; Funkhouser, E.; Chavers, L. P.; Stamm, A. M.; Waites, Ken B.

In: Journal of Hospital Infection, Vol. 53, No. 3, 03.2003, p. 159-171.

Research output: Contribution to journal › Review article › peer-review

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title = "Vancomycin-resistant enterococci: 15 years and counting",

abstract = "We review the history of vancomycin-resistant enterococci (VRE) and propose a causal model illustrating the roles of exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and prevalence of VRE in the progression from potential VRE reservoirs to active disease in hospitalized patients. Differences in VRE colonization and VRE infection are discussed with respect to hospital surveillance methodology and implications for interventions. We further document clonal transmission of VRE in a large, urban, teaching hospital and demonstrate VRE susceptibility to a wide array of antimicrobial agents. This model can guide the identification of mutable factors that are focal points for intervention.",

keywords = "Antimicrobials, Enterococci, Resistance, Vancomycin",

author = "Chavers, {L. S.} and Moser, {S. A.} and Benjamin, {W. H.} and Banks, {S. E.} and Steinhauer, {J. R.} and Smith, {A. M.} and Johnson, {C. N.} and E. Funkhouser and Chavers, {L. P.} and Stamm, {A. M.} and Waites, {Ken B.}",

note = "Funding Information: The authors wish to thank Sten H. Vermund, Fabio Barbone, Michael Hardin, Vicki Fitzgerald, April Calloway, Nancy Olvey, Lisa Contarupis, Stacy Aaron, Brandy Boutin, and Jenny Huang for their assistance in preparing this review. Some of this work was supported by a grant from Wyeth Pharmaceutical Co. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2003",

month = mar,

doi = "10.1053/jhin.2002.1375",

language = "English (US)",

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pages = "159--171",

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AU - Chavers, L. S.

AU - Moser, S. A.

AU - Benjamin, W. H.

AU - Banks, S. E.

AU - Steinhauer, J. R.

AU - Smith, A. M.

AU - Johnson, C. N.

AU - Funkhouser, E.

AU - Chavers, L. P.

AU - Stamm, A. M.

AU - Waites, Ken B.

N1 - Funding Information: The authors wish to thank Sten H. Vermund, Fabio Barbone, Michael Hardin, Vicki Fitzgerald, April Calloway, Nancy Olvey, Lisa Contarupis, Stacy Aaron, Brandy Boutin, and Jenny Huang for their assistance in preparing this review. Some of this work was supported by a grant from Wyeth Pharmaceutical Co. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2003/3

Y1 - 2003/3

N2 - We review the history of vancomycin-resistant enterococci (VRE) and propose a causal model illustrating the roles of exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and prevalence of VRE in the progression from potential VRE reservoirs to active disease in hospitalized patients. Differences in VRE colonization and VRE infection are discussed with respect to hospital surveillance methodology and implications for interventions. We further document clonal transmission of VRE in a large, urban, teaching hospital and demonstrate VRE susceptibility to a wide array of antimicrobial agents. This model can guide the identification of mutable factors that are focal points for intervention.

AB - We review the history of vancomycin-resistant enterococci (VRE) and propose a causal model illustrating the roles of exposure to VRE reservoirs, patient characteristics, antimicrobial exposure, and prevalence of VRE in the progression from potential VRE reservoirs to active disease in hospitalized patients. Differences in VRE colonization and VRE infection are discussed with respect to hospital surveillance methodology and implications for interventions. We further document clonal transmission of VRE in a large, urban, teaching hospital and demonstrate VRE susceptibility to a wide array of antimicrobial agents. This model can guide the identification of mutable factors that are focal points for intervention.

KW - Antimicrobials

KW - Enterococci

KW - Resistance

KW - Vancomycin

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Vancomycin-resistant enterococci: 15 years and counting

Abstract

Keywords

ASJC Scopus subject areas

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