Valvular strands and cerebral ischemia

Effect of demographics and strand characteristics

J. Kirk Roberts, Iqbal Omarali, Marco R. Di Tullio, Robert R. Sciacca, Ralph L Sacco, Shunichi Homma

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background and Purpose: Valvular strands, thin filamentous material attached to the mitral or aortic valve, are seen during transesophageal echocardiography and have been associated with stroke. Little is known about this association in different age, sex, and race-ethnic subgroups and the effect of various strand characteristics on this association. Methods: From patients referred for transesophageal echocardiography, 73 patients with recent ischemic stroke (68) or transient ischemic attack (5) were age matched to 73 stroke-and transient ischemic attack-free control subjects. The association between valvular strands and cerebral ischemia was evaluated for the overall group and demographic subgroups. The effect of strand location, length, number, and valve thickness was also determined. Results: An association between cerebral ischemia and valvular strands was observed (odds ratio [OR]=4.4; 95% confidence interval [CI]=2.0 to 9.6). The association was found for both men and women and among all three race-ethnic groups. The OR was greater in those who were younger (12.5 [95% CI=2.4 to 64.5] for age <60, 4.8 [95% CI=1.3 to 18.2] for age 60 to 69, and 1.8 [95% CI=0.5 to 6.4] for age ≤70 years). Strands on both the mitral (OR=3.5; 95% CI=1.5 to 7.9) and aortic (OR=3.7; 95% CI=1.1 to 11.9) valve were associated with cerebral ischemia, whereas the number and length of strands were not. The effect of strands was independent of mitral or aortic valve thickness. Conclusions: Valvular strands, whether mitral or aortic, are associated with ischemic stroke, especially among younger persons.

Original languageEnglish
Pages (from-to)2185-2188
Number of pages4
JournalStroke
Volume28
Issue number11
StatePublished - Nov 1 1997
Externally publishedYes

Fingerprint

Brain Ischemia
Demography
Confidence Intervals
Stroke
Odds Ratio
Transient Ischemic Attack
Transesophageal Echocardiography
Aortic Valve
Mitral Valve
Ethnic Groups

Keywords

  • Cardiovascular disorders
  • Cerebral ischemia
  • Risk factors
  • Young adults

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Roberts, J. K., Omarali, I., Di Tullio, M. R., Sciacca, R. R., Sacco, R. L., & Homma, S. (1997). Valvular strands and cerebral ischemia: Effect of demographics and strand characteristics. Stroke, 28(11), 2185-2188.

Valvular strands and cerebral ischemia : Effect of demographics and strand characteristics. / Roberts, J. Kirk; Omarali, Iqbal; Di Tullio, Marco R.; Sciacca, Robert R.; Sacco, Ralph L; Homma, Shunichi.

In: Stroke, Vol. 28, No. 11, 01.11.1997, p. 2185-2188.

Research output: Contribution to journalArticle

Roberts, JK, Omarali, I, Di Tullio, MR, Sciacca, RR, Sacco, RL & Homma, S 1997, 'Valvular strands and cerebral ischemia: Effect of demographics and strand characteristics', Stroke, vol. 28, no. 11, pp. 2185-2188.
Roberts JK, Omarali I, Di Tullio MR, Sciacca RR, Sacco RL, Homma S. Valvular strands and cerebral ischemia: Effect of demographics and strand characteristics. Stroke. 1997 Nov 1;28(11):2185-2188.
Roberts, J. Kirk ; Omarali, Iqbal ; Di Tullio, Marco R. ; Sciacca, Robert R. ; Sacco, Ralph L ; Homma, Shunichi. / Valvular strands and cerebral ischemia : Effect of demographics and strand characteristics. In: Stroke. 1997 ; Vol. 28, No. 11. pp. 2185-2188.
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abstract = "Background and Purpose: Valvular strands, thin filamentous material attached to the mitral or aortic valve, are seen during transesophageal echocardiography and have been associated with stroke. Little is known about this association in different age, sex, and race-ethnic subgroups and the effect of various strand characteristics on this association. Methods: From patients referred for transesophageal echocardiography, 73 patients with recent ischemic stroke (68) or transient ischemic attack (5) were age matched to 73 stroke-and transient ischemic attack-free control subjects. The association between valvular strands and cerebral ischemia was evaluated for the overall group and demographic subgroups. The effect of strand location, length, number, and valve thickness was also determined. Results: An association between cerebral ischemia and valvular strands was observed (odds ratio [OR]=4.4; 95{\%} confidence interval [CI]=2.0 to 9.6). The association was found for both men and women and among all three race-ethnic groups. The OR was greater in those who were younger (12.5 [95{\%} CI=2.4 to 64.5] for age <60, 4.8 [95{\%} CI=1.3 to 18.2] for age 60 to 69, and 1.8 [95{\%} CI=0.5 to 6.4] for age ≤70 years). Strands on both the mitral (OR=3.5; 95{\%} CI=1.5 to 7.9) and aortic (OR=3.7; 95{\%} CI=1.1 to 11.9) valve were associated with cerebral ischemia, whereas the number and length of strands were not. The effect of strands was independent of mitral or aortic valve thickness. Conclusions: Valvular strands, whether mitral or aortic, are associated with ischemic stroke, especially among younger persons.",
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AU - Omarali, Iqbal

AU - Di Tullio, Marco R.

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AU - Sacco, Ralph L

AU - Homma, Shunichi

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N2 - Background and Purpose: Valvular strands, thin filamentous material attached to the mitral or aortic valve, are seen during transesophageal echocardiography and have been associated with stroke. Little is known about this association in different age, sex, and race-ethnic subgroups and the effect of various strand characteristics on this association. Methods: From patients referred for transesophageal echocardiography, 73 patients with recent ischemic stroke (68) or transient ischemic attack (5) were age matched to 73 stroke-and transient ischemic attack-free control subjects. The association between valvular strands and cerebral ischemia was evaluated for the overall group and demographic subgroups. The effect of strand location, length, number, and valve thickness was also determined. Results: An association between cerebral ischemia and valvular strands was observed (odds ratio [OR]=4.4; 95% confidence interval [CI]=2.0 to 9.6). The association was found for both men and women and among all three race-ethnic groups. The OR was greater in those who were younger (12.5 [95% CI=2.4 to 64.5] for age <60, 4.8 [95% CI=1.3 to 18.2] for age 60 to 69, and 1.8 [95% CI=0.5 to 6.4] for age ≤70 years). Strands on both the mitral (OR=3.5; 95% CI=1.5 to 7.9) and aortic (OR=3.7; 95% CI=1.1 to 11.9) valve were associated with cerebral ischemia, whereas the number and length of strands were not. The effect of strands was independent of mitral or aortic valve thickness. Conclusions: Valvular strands, whether mitral or aortic, are associated with ischemic stroke, especially among younger persons.

AB - Background and Purpose: Valvular strands, thin filamentous material attached to the mitral or aortic valve, are seen during transesophageal echocardiography and have been associated with stroke. Little is known about this association in different age, sex, and race-ethnic subgroups and the effect of various strand characteristics on this association. Methods: From patients referred for transesophageal echocardiography, 73 patients with recent ischemic stroke (68) or transient ischemic attack (5) were age matched to 73 stroke-and transient ischemic attack-free control subjects. The association between valvular strands and cerebral ischemia was evaluated for the overall group and demographic subgroups. The effect of strand location, length, number, and valve thickness was also determined. Results: An association between cerebral ischemia and valvular strands was observed (odds ratio [OR]=4.4; 95% confidence interval [CI]=2.0 to 9.6). The association was found for both men and women and among all three race-ethnic groups. The OR was greater in those who were younger (12.5 [95% CI=2.4 to 64.5] for age <60, 4.8 [95% CI=1.3 to 18.2] for age 60 to 69, and 1.8 [95% CI=0.5 to 6.4] for age ≤70 years). Strands on both the mitral (OR=3.5; 95% CI=1.5 to 7.9) and aortic (OR=3.7; 95% CI=1.1 to 11.9) valve were associated with cerebral ischemia, whereas the number and length of strands were not. The effect of strands was independent of mitral or aortic valve thickness. Conclusions: Valvular strands, whether mitral or aortic, are associated with ischemic stroke, especially among younger persons.

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KW - Risk factors

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