Value added

functional MR imaging in management of bone and soft tissue sarcomas

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: MRI plays a crucial role in the initial diagnosis, treatment planning, and long-term management of bone and soft tissue sarcomas. Technological advances have enabled improvements in both delineation of anatomic detail, and in functional imaging techniques that interrogate tissues at the cellular level. This bears particular relevance in sarcomas as morphological parameters alone do not necessarily correlate with treatment response and prognosis. Here, we describe recent developments in advanced MRI techniques, including chemical-shift MRI, diffusion-weighted imaging (DWI), MR spectroscopy (MRS), and dynamic contrast enhanced (DCE) MRI.

RECENT FINDINGS: Chemical-shift MRI allows robust discrimination of marrow infiltrating neoplasms from benign red marrow. DWI reveals tumor cellularity, and aids in distinguishing benign and malignant tumors along with the assessment of treatment response. MRS is technically challenging in the musculoskeletal system, but shows promise as a means to noninvasively assess metabolic aberrations in a variety of sarcomas. DCE is particularly suited to treatment response evaluation, in which traditional size-based assessment criteria may underestimate efficacy in clinical trials.

SUMMARY: Functional MRI techniques offer novel imaging biomarkers that effectively complement conventional MRI in the assessment of bone and soft tissue sarcomas at all stages of patient care.

Original languageEnglish (US)
Pages (from-to)323-331
Number of pages9
JournalCurrent Opinion in Oncology
Volume27
Issue number4
DOIs
StatePublished - Jul 1 2015

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Sarcoma
Bone and Bones
Magnetic Resonance Spectroscopy
Bone Marrow
Musculoskeletal System
Neoplasms
Diffusion Magnetic Resonance Imaging
Therapeutics
Patient Care
Biomarkers
Magnetic Resonance Imaging
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

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Value added : functional MR imaging in management of bone and soft tissue sarcomas. / Subhawong, Ty; Wilky, Breelyn A.

In: Current Opinion in Oncology, Vol. 27, No. 4, 01.07.2015, p. 323-331.

Research output: Contribution to journalArticle

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