Valproate: A practical review of its uses in neurological and psychiatric disorders

Andres M Kanner, Antoaneta Balabanov

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Valproate is an antiepileptic drug with a wide spectrum efficacy in the management of various types of seizures and epileptic syndromes. In addition to its efficacy in epilepsy, valproate has been found to have therapeutic effects in various psychiatric disorders, including manic states, bipolar, panic and schizophreniform disorders and in the prevention and acute treatment of migraine. Valproate is available in various formulations that differ primarily in their absorption profiles. The purpose of this review article is to highlight the most important pharmacokinetic and pharmacodynamic properties of this drug that all clinicians should be aware of when using it as an antiepileptic, antimigraine, or mood-stabilizing agent. We review its use with other common antiepileptics or psychotropic drugs and the pharmacokinetic interactions with commonly used drugs. We also review its tolerance and toxicity profile in the various age-groups and devote a section to the particular problems associated with its use in patients with renal and hepatic failure and in women of gestational age.

Original languageEnglish (US)
Pages (from-to)151-165
Number of pages15
JournalExpert Review of Neurotherapeutics
Volume2
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Valproic Acid
Nervous System Diseases
Bipolar Disorder
Anticonvulsants
Psychiatry
Epilepsy
Pharmacokinetics
Excipients
Panic Disorder
Psychotropic Drugs
Liver Failure
Therapeutic Uses
Migraine Disorders
Drug Interactions
Pharmaceutical Preparations
Psychotic Disorders
Gestational Age
Renal Insufficiency
Age Groups
Therapeutics

Keywords

  • Absence seizures
  • Bipolar disorder
  • Epilepsy
  • Hepatic failure
  • Infantile spasms
  • Juvenile myoclonic epilepsy
  • Lennox-Gastaut syndrome
  • Migraine
  • Neural tube defect
  • Pancreatitis
  • Panic disorder
  • Parenteral valproate
  • Partial seizure disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Valproate : A practical review of its uses in neurological and psychiatric disorders. / Kanner, Andres M; Balabanov, Antoaneta.

In: Expert Review of Neurotherapeutics, Vol. 2, No. 2, 2002, p. 151-165.

Research output: Contribution to journalArticle

@article{7b028bae03c94fc7896f0a5f101045b7,
title = "Valproate: A practical review of its uses in neurological and psychiatric disorders",
abstract = "Valproate is an antiepileptic drug with a wide spectrum efficacy in the management of various types of seizures and epileptic syndromes. In addition to its efficacy in epilepsy, valproate has been found to have therapeutic effects in various psychiatric disorders, including manic states, bipolar, panic and schizophreniform disorders and in the prevention and acute treatment of migraine. Valproate is available in various formulations that differ primarily in their absorption profiles. The purpose of this review article is to highlight the most important pharmacokinetic and pharmacodynamic properties of this drug that all clinicians should be aware of when using it as an antiepileptic, antimigraine, or mood-stabilizing agent. We review its use with other common antiepileptics or psychotropic drugs and the pharmacokinetic interactions with commonly used drugs. We also review its tolerance and toxicity profile in the various age-groups and devote a section to the particular problems associated with its use in patients with renal and hepatic failure and in women of gestational age.",
keywords = "Absence seizures, Bipolar disorder, Epilepsy, Hepatic failure, Infantile spasms, Juvenile myoclonic epilepsy, Lennox-Gastaut syndrome, Migraine, Neural tube defect, Pancreatitis, Panic disorder, Parenteral valproate, Partial seizure disorders",
author = "Kanner, {Andres M} and Antoaneta Balabanov",
year = "2002",
doi = "10.1586/14737175.2.2.151",
language = "English (US)",
volume = "2",
pages = "151--165",
journal = "Expert Review of Neurotherapeutics",
issn = "1473-7175",
publisher = "Expert Reviews Ltd.",
number = "2",

}

TY - JOUR

T1 - Valproate

T2 - A practical review of its uses in neurological and psychiatric disorders

AU - Kanner, Andres M

AU - Balabanov, Antoaneta

PY - 2002

Y1 - 2002

N2 - Valproate is an antiepileptic drug with a wide spectrum efficacy in the management of various types of seizures and epileptic syndromes. In addition to its efficacy in epilepsy, valproate has been found to have therapeutic effects in various psychiatric disorders, including manic states, bipolar, panic and schizophreniform disorders and in the prevention and acute treatment of migraine. Valproate is available in various formulations that differ primarily in their absorption profiles. The purpose of this review article is to highlight the most important pharmacokinetic and pharmacodynamic properties of this drug that all clinicians should be aware of when using it as an antiepileptic, antimigraine, or mood-stabilizing agent. We review its use with other common antiepileptics or psychotropic drugs and the pharmacokinetic interactions with commonly used drugs. We also review its tolerance and toxicity profile in the various age-groups and devote a section to the particular problems associated with its use in patients with renal and hepatic failure and in women of gestational age.

AB - Valproate is an antiepileptic drug with a wide spectrum efficacy in the management of various types of seizures and epileptic syndromes. In addition to its efficacy in epilepsy, valproate has been found to have therapeutic effects in various psychiatric disorders, including manic states, bipolar, panic and schizophreniform disorders and in the prevention and acute treatment of migraine. Valproate is available in various formulations that differ primarily in their absorption profiles. The purpose of this review article is to highlight the most important pharmacokinetic and pharmacodynamic properties of this drug that all clinicians should be aware of when using it as an antiepileptic, antimigraine, or mood-stabilizing agent. We review its use with other common antiepileptics or psychotropic drugs and the pharmacokinetic interactions with commonly used drugs. We also review its tolerance and toxicity profile in the various age-groups and devote a section to the particular problems associated with its use in patients with renal and hepatic failure and in women of gestational age.

KW - Absence seizures

KW - Bipolar disorder

KW - Epilepsy

KW - Hepatic failure

KW - Infantile spasms

KW - Juvenile myoclonic epilepsy

KW - Lennox-Gastaut syndrome

KW - Migraine

KW - Neural tube defect

KW - Pancreatitis

KW - Panic disorder

KW - Parenteral valproate

KW - Partial seizure disorders

UR - http://www.scopus.com/inward/record.url?scp=0036282286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036282286&partnerID=8YFLogxK

U2 - 10.1586/14737175.2.2.151

DO - 10.1586/14737175.2.2.151

M3 - Article

C2 - 19810997

AN - SCOPUS:0036282286

VL - 2

SP - 151

EP - 165

JO - Expert Review of Neurotherapeutics

JF - Expert Review of Neurotherapeutics

SN - 1473-7175

IS - 2

ER -