Validation of the Spanish version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)

Daniela Di Capua, Maria Eugenia Garcia-Garcia, Abilio Reig-Ferrer, Manuel Fuentes-Ferrer, Rafael Toledano, Antonio Gil-Nagel, Sara Garcia-Ptaceck, Monica Kurtis, Andres M. Kanner, Irene Garcia-Morales

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Introduction: To translate and validate into Spanish (Spain) the screening instrument of major depressive episodes (MDEs), Neurological Disorders Depression Inventory in Epilepsy (NDDI-E), in patients with epilepsy. Methods: A total of 121 outpatients, aged 18. years and older, with a diagnosis of epilepsy were included. The diagnosis of a current major depressive episode (MDE) was established with the Mini International Neuropsychiatric Interview (MINI). Results: A diagnosis of current MDE was established in 20% of the patients with the MINI. Receiver operator characteristics (ROC) analysis showed an area under the curve of 0.89, with an internal consistency of 0.78. At a cutoff score > 13, 22% of patients were considered to suffer from MDE with the NDDI-E (sensitivity: 84%; specificity: 78%; positive predictive value: 64.7%; and negative predictive value: 92.2%). Discussion: The Spanish-Spain version of the NDDI-E appears to be a good screening instrument to identify MDE.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalEpilepsy and Behavior
Issue number4
StatePublished - Aug 2012
Externally publishedYes


  • Major depressive episode
  • NDDI-E
  • Patients with epilepsy
  • Psychiatric comorbidity
  • Screening tool

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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