Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults

Peter H. Klijn, Henk F. van Stel, Alexandra Quittner, Janjaap van der Net, Wytze Doeleman, Cees P. van der Schans, Cornelis K. van der Ent

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: This study assesses the reliability and validity of the Dutch version of a disease-specific measure of health-related quality of life (HRQOL) for adolescents and adults with CF (CFQ-14+). The 47-item CFQ-14+ covers nine domains, three symptom scales and one health perception scale. Methods: To assess psychometric characteristics of the CFQ-14+, cross-sectional (homogeneity, discriminative and construct validity) and test-retest designs were used. Eighty-four adolescents and adults with CF (mean age: 21.4 years, range 14.0-46.5 years) and a wide range of lung function (mean FEV1: 59,9% predicted, range 15-121%) completed the questionnaire during a routine visit. Results: Internal consistency was acceptable for most domains of the CFQ-14+ (α=0.43-0.92) and test-retest reliability was high for all domain scores (0.72-0.98). Several domains of the CFQ-14+ were able to differentiate between individuals with varying disease severity and between nourished and malnourished patients. Construct validity of the questionnaire was fair, with moderate to strong correlation between physically orientated domains and pulmonary function (rs=0.36-0.62). Conclusion: The results demonstrate that the CFQ-14+ questionnaire is a well-validated measure of HRQOL assessment in adolescents and adults with CF.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalJournal of Cystic Fibrosis
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2004

Fingerprint

Cystic Fibrosis
Reproducibility of Results
Quality of Life
Surveys and Questionnaires
Lung
Psychometrics
Health

Keywords

  • Cystic fibrosis
  • Health-related quality of life
  • Psychometrics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Klijn, P. H., van Stel, H. F., Quittner, A., van der Net, J., Doeleman, W., van der Schans, C. P., & van der Ent, C. K. (2004). Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults. Journal of Cystic Fibrosis, 3(1), 29-36. https://doi.org/10.1016/j.jcf.2003.12.006

Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults. / Klijn, Peter H.; van Stel, Henk F.; Quittner, Alexandra; van der Net, Janjaap; Doeleman, Wytze; van der Schans, Cees P.; van der Ent, Cornelis K.

In: Journal of Cystic Fibrosis, Vol. 3, No. 1, 01.03.2004, p. 29-36.

Research output: Contribution to journalArticle

Klijn, PH, van Stel, HF, Quittner, A, van der Net, J, Doeleman, W, van der Schans, CP & van der Ent, CK 2004, 'Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults', Journal of Cystic Fibrosis, vol. 3, no. 1, pp. 29-36. https://doi.org/10.1016/j.jcf.2003.12.006
Klijn PH, van Stel HF, Quittner A, van der Net J, Doeleman W, van der Schans CP et al. Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults. Journal of Cystic Fibrosis. 2004 Mar 1;3(1):29-36. https://doi.org/10.1016/j.jcf.2003.12.006
Klijn, Peter H. ; van Stel, Henk F. ; Quittner, Alexandra ; van der Net, Janjaap ; Doeleman, Wytze ; van der Schans, Cees P. ; van der Ent, Cornelis K. / Validation of the Dutch cystic fibrosis questionnaire (CFQ) in adolescents and adults. In: Journal of Cystic Fibrosis. 2004 ; Vol. 3, No. 1. pp. 29-36.
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