Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study

Jay M Sosenko, Jay S Skyler, Jeffrey Mahon, Jeffrey P. Krischer, Craig A. Beam, David C. Boulware, Carla J. Greenbaum, Lisa Rafkin, Catherine Cowie, David Cuthbertson, Jerry P. Palmer

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE - We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed fromthe Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS - Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts. RESULTS - Receiver-operating characteristic curve areas for the DPTRSwere substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <6.50 (<0.10 and <0.20, respectively). Thresholds ≥7.50 were indicative of high risk in both cohorts (2-year risks: 0.49 in the TNNHS and 0.51 in DPT-1). CONCLUSIONS - The DPTRS is an accurate and robust predictor of type 1 diabetes in autoantibody-positive populations.

Original languageEnglish
Pages (from-to)1785-1787
Number of pages3
JournalDiabetes Care
Volume34
Issue number8
DOIs
StatePublished - Aug 1 2011

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Natural History
Type 1 Diabetes Mellitus
ROC Curve
Incidence
Autoantibodies
Research Design
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study. / Sosenko, Jay M; Skyler, Jay S; Mahon, Jeffrey; Krischer, Jeffrey P.; Beam, Craig A.; Boulware, David C.; Greenbaum, Carla J.; Rafkin, Lisa; Cowie, Catherine; Cuthbertson, David; Palmer, Jerry P.

In: Diabetes Care, Vol. 34, No. 8, 01.08.2011, p. 1785-1787.

Research output: Contribution to journalArticle

Sosenko, JM, Skyler, JS, Mahon, J, Krischer, JP, Beam, CA, Boulware, DC, Greenbaum, CJ, Rafkin, L, Cowie, C, Cuthbertson, D & Palmer, JP 2011, 'Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study', Diabetes Care, vol. 34, no. 8, pp. 1785-1787. https://doi.org/10.2337/dc11-0641
Sosenko, Jay M ; Skyler, Jay S ; Mahon, Jeffrey ; Krischer, Jeffrey P. ; Beam, Craig A. ; Boulware, David C. ; Greenbaum, Carla J. ; Rafkin, Lisa ; Cowie, Catherine ; Cuthbertson, David ; Palmer, Jerry P. / Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study. In: Diabetes Care. 2011 ; Vol. 34, No. 8. pp. 1785-1787.
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