Abstract
OBJECTIVE - We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed fromthe Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS - Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts. RESULTS - Receiver-operating characteristic curve areas for the DPTRSwere substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <6.50 (<0.10 and <0.20, respectively). Thresholds ≥7.50 were indicative of high risk in both cohorts (2-year risks: 0.49 in the TNNHS and 0.51 in DPT-1). CONCLUSIONS - The DPTRS is an accurate and robust predictor of type 1 diabetes in autoantibody-positive populations.
| Original language | English |
|---|---|
| Pages (from-to) | 1785-1787 |
| Number of pages | 3 |
| Journal | Diabetes Care |
| Volume | 34 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2011 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialized Nursing
Cite this
Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study. / Sosenko, Jay M; Skyler, Jay S; Mahon, Jeffrey; Krischer, Jeffrey P.; Beam, Craig A.; Boulware, David C.; Greenbaum, Carla J.; Rafkin, Lisa; Cowie, Catherine; Cuthbertson, David; Palmer, Jerry P.
In: Diabetes Care, Vol. 34, No. 8, 01.08.2011, p. 1785-1787.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study
AU - Sosenko, Jay M
AU - Skyler, Jay S
AU - Mahon, Jeffrey
AU - Krischer, Jeffrey P.
AU - Beam, Craig A.
AU - Boulware, David C.
AU - Greenbaum, Carla J.
AU - Rafkin, Lisa
AU - Cowie, Catherine
AU - Cuthbertson, David
AU - Palmer, Jerry P.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - OBJECTIVE - We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed fromthe Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS - Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts. RESULTS - Receiver-operating characteristic curve areas for the DPTRSwere substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <6.50 (<0.10 and <0.20, respectively). Thresholds ≥7.50 were indicative of high risk in both cohorts (2-year risks: 0.49 in the TNNHS and 0.51 in DPT-1). CONCLUSIONS - The DPTRS is an accurate and robust predictor of type 1 diabetes in autoantibody-positive populations.
AB - OBJECTIVE - We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed fromthe Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS - Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts. RESULTS - Receiver-operating characteristic curve areas for the DPTRSwere substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <6.50 (<0.10 and <0.20, respectively). Thresholds ≥7.50 were indicative of high risk in both cohorts (2-year risks: 0.49 in the TNNHS and 0.51 in DPT-1). CONCLUSIONS - The DPTRS is an accurate and robust predictor of type 1 diabetes in autoantibody-positive populations.
UR - http://www.scopus.com/inward/record.url?scp=84856015613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856015613&partnerID=8YFLogxK
U2 - 10.2337/dc11-0641
DO - 10.2337/dc11-0641
M3 - Article
C2 - 21680724
AN - SCOPUS:84856015613
VL - 34
SP - 1785
EP - 1787
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 8
ER -