Validation of genome-wide prostate cancer associations in men of african descent

Bao Li Chang, Elaine Spangler, Stephen Gallagher, Christopher A. Haiman, Brian Henderson, William Isaacs, Marnita L. Benford, Lacreis R. Kidd, Kathleen Cooney, Sara Strom, Sue Ann Ingles, Mariana C. Stern, Roman Corral, Amit D. Joshi, Jianfeng Xu, Veda N. Giri, Benjamin Rybicki, Christine Neslund-Dudas, Adam S. Kibel, Ian M. ThompsonRobin J. Leach, Elaine A. Ostrander, Janet L. Stanford, John Witte, Graham Casey, Rosalind Eeles, Ann W. Hsing, Stephen Chanock, Jennifer Hu, Esther M. John, Jong Park, Klara Stefflova, Charnita Zeigler-Johnson, Timothy R. Rebbeck

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Chang, B. L., Spangler, E., Gallagher, S., Haiman, C. A., Henderson, B., Isaacs, W., Benford, M. L., Kidd, L. R., Cooney, K., Strom, S., Ingles, S. A., Stern, M. C., Corral, R., Joshi, A. D., Xu, J., Giri, V. N., Rybicki, B., Neslund-Dudas, C., Kibel, A. S., ... Rebbeck, T. R. (2011). Validation of genome-wide prostate cancer associations in men of african descent. Cancer Epidemiology Biomarkers and Prevention, 20(1), 23-32. https://doi.org/10.1158/1055-9965.EPI-10-0698