Validation of a Quality of Life Questionnaire for Bronchiectasis

Psychometric analyses of the Spanish QOL-B-V3.0

Casilda Olveira, Gabriel Olveira, Francisco Espildora, Rosa Maria Giron, Gerard Muñoz, Alexandra Quittner, Miguel Angel Martinez-Garcia

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: Bronchiectasis is a chronic disease, leading to worsening of health-related quality of life. This study evaluated the psychometric properties of a new patient-reported outcome for non-cystic fibrosis bronchiectasis, the Quality of Life Questionnaire Bronchiectasis, translated into Spanish (QOL-B-Sp-V3.0). Methods: This prospective study recruited clinically stable patients with non-cystic fibrosis bronchiectasis at 4 Spanish centers. Health status was assessed with multiple indicators (dyspnea, exacerbations, bronchorrhea, etc.), microbiological, radiological, spirometric, and anthropometric parameters plus St-George Respiratory Questionnaire (SGRQ). Psychometric analyses included internal consistency, test-retest reliability, convergent validity, predictive validity, and responsivity to change. Results: The 207 stable patients (mean age 57.2 years) had a Bhalla score of 11.53 ± 7.39 and FEV1% of 68.3 ± 22.2 %. One hundred and sixty-one stable patients repeated the test 2 weeks later, and 80 patients who had an exacerbation within 6 months of the assessment also repeated it. Internal consistency was high across all scales (Cronbach's alpha >0.70). Thirty-six of 37 items correlated more strongly with their assigned scale than a competing scale. Test-retest coefficients were strong (intraclass correlations r = 0.68-0.88). All scales, except Treatment Burden, discriminated significantly between patients with mild, moderate, and severe disease according to FEV1% and other respiratory parameters. Strong convergence was found between the QOL-B-Sp-V3.0 and SGRQ. Significant correlations were found between QOL-B-Sp-V3.0 and various clinical, spirometric, radiological, and anthropometric variables. Significant differences were found on all QOL-B-Sp-V3.0 scales, except emotional functioning, between the baseline responses and onset of an exacerbation; robust sensitivity to change was observed on the Respiratory Symptoms scale. Conclusions: The QOL-B-Sp-V3.0 questionnaire demonstrated strong reliability and validity. Scores were reproducible after 2 weeks, and it discriminated between patients who varied in severity and was responsive to changes related to exacerbation.

Original languageEnglish
Pages (from-to)1279-1292
Number of pages14
JournalQuality of Life Research
Volume23
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Bronchiectasis
Psychometrics
Quality of Life
Reproducibility of Results
Fibrosis
Dyspnea
Health Status
Surveys and Questionnaires
Chronic Disease
Prospective Studies

Keywords

  • Bronchiectasis
  • Forced spirometry volume in the first second
  • Health-related quality of life
  • Patient-reported outcome

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Olveira, C., Olveira, G., Espildora, F., Giron, R. M., Muñoz, G., Quittner, A., & Martinez-Garcia, M. A. (2014). Validation of a Quality of Life Questionnaire for Bronchiectasis: Psychometric analyses of the Spanish QOL-B-V3.0. Quality of Life Research, 23(4), 1279-1292. https://doi.org/10.1007/s11136-013-0560-0

Validation of a Quality of Life Questionnaire for Bronchiectasis : Psychometric analyses of the Spanish QOL-B-V3.0. / Olveira, Casilda; Olveira, Gabriel; Espildora, Francisco; Giron, Rosa Maria; Muñoz, Gerard; Quittner, Alexandra; Martinez-Garcia, Miguel Angel.

In: Quality of Life Research, Vol. 23, No. 4, 01.01.2014, p. 1279-1292.

Research output: Contribution to journalArticle

Olveira, C, Olveira, G, Espildora, F, Giron, RM, Muñoz, G, Quittner, A & Martinez-Garcia, MA 2014, 'Validation of a Quality of Life Questionnaire for Bronchiectasis: Psychometric analyses of the Spanish QOL-B-V3.0', Quality of Life Research, vol. 23, no. 4, pp. 1279-1292. https://doi.org/10.1007/s11136-013-0560-0
Olveira, Casilda ; Olveira, Gabriel ; Espildora, Francisco ; Giron, Rosa Maria ; Muñoz, Gerard ; Quittner, Alexandra ; Martinez-Garcia, Miguel Angel. / Validation of a Quality of Life Questionnaire for Bronchiectasis : Psychometric analyses of the Spanish QOL-B-V3.0. In: Quality of Life Research. 2014 ; Vol. 23, No. 4. pp. 1279-1292.
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N2 - Purpose: Bronchiectasis is a chronic disease, leading to worsening of health-related quality of life. This study evaluated the psychometric properties of a new patient-reported outcome for non-cystic fibrosis bronchiectasis, the Quality of Life Questionnaire Bronchiectasis, translated into Spanish (QOL-B-Sp-V3.0). Methods: This prospective study recruited clinically stable patients with non-cystic fibrosis bronchiectasis at 4 Spanish centers. Health status was assessed with multiple indicators (dyspnea, exacerbations, bronchorrhea, etc.), microbiological, radiological, spirometric, and anthropometric parameters plus St-George Respiratory Questionnaire (SGRQ). Psychometric analyses included internal consistency, test-retest reliability, convergent validity, predictive validity, and responsivity to change. Results: The 207 stable patients (mean age 57.2 years) had a Bhalla score of 11.53 ± 7.39 and FEV1% of 68.3 ± 22.2 %. One hundred and sixty-one stable patients repeated the test 2 weeks later, and 80 patients who had an exacerbation within 6 months of the assessment also repeated it. Internal consistency was high across all scales (Cronbach's alpha >0.70). Thirty-six of 37 items correlated more strongly with their assigned scale than a competing scale. Test-retest coefficients were strong (intraclass correlations r = 0.68-0.88). All scales, except Treatment Burden, discriminated significantly between patients with mild, moderate, and severe disease according to FEV1% and other respiratory parameters. Strong convergence was found between the QOL-B-Sp-V3.0 and SGRQ. Significant correlations were found between QOL-B-Sp-V3.0 and various clinical, spirometric, radiological, and anthropometric variables. Significant differences were found on all QOL-B-Sp-V3.0 scales, except emotional functioning, between the baseline responses and onset of an exacerbation; robust sensitivity to change was observed on the Respiratory Symptoms scale. Conclusions: The QOL-B-Sp-V3.0 questionnaire demonstrated strong reliability and validity. Scores were reproducible after 2 weeks, and it discriminated between patients who varied in severity and was responsive to changes related to exacerbation.

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