Vagus Nerve Stimulation in Rodent Models: An Overview of Technical Considerations

Crystal M. Noller, Yaakov A. Levine, Timur M. Urakov, Joshua P. Aronson, Mark S. Nash

Research output: Contribution to journalReview article

Abstract

Over the last several decades, vagus nerve stimulation (VNS) has evolved from a treatment for select neuropsychiatric disorders to one that holds promise in treating numerous inflammatory conditions. Growing interest has focused on the use of VNS for other indications, such as heart failure, rheumatoid arthritis, inflammatory bowel disease, ischemic stroke, and traumatic brain injury. As pre-clinical research often guides expansion into new clinical avenues, animal models of VNS have also increased in recent years. To advance this promising treatment, however, there are a number of experimental parameters that must be considered when planning a study, such as physiology of the vagus nerve, electrical stimulation parameters, electrode design, stimulation equipment, and microsurgical technique. In this review, we discuss these important considerations and how a combination of clinically relevant stimulation parameters can be used to achieve beneficial therapeutic results in pre-clinical studies of sub-acute to chronic VNS, and provide a practical guide for performing this work in rodent models. Finally, by integrating clinical and pre-clinical research, we present indeterminate issues as opportunities for future research.

Original languageEnglish (US)
Article number911
JournalFrontiers in Neuroscience
Volume13
DOIs
StatePublished - Sep 4 2019
Externally publishedYes

Fingerprint

Vagus Nerve Stimulation
Rodentia
Equipment Design
Inflammatory Bowel Diseases
Research
Electric Stimulation
Rheumatoid Arthritis
Electrodes
Therapeutics
Animal Models
Heart Failure
Stroke

Keywords

  • electrical stimulation
  • nerve cuff electrode
  • neuromodulation
  • vagus nerve
  • vagus nerve stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vagus Nerve Stimulation in Rodent Models : An Overview of Technical Considerations. / Noller, Crystal M.; Levine, Yaakov A.; Urakov, Timur M.; Aronson, Joshua P.; Nash, Mark S.

In: Frontiers in Neuroscience, Vol. 13, 911, 04.09.2019.

Research output: Contribution to journalReview article

Noller, Crystal M. ; Levine, Yaakov A. ; Urakov, Timur M. ; Aronson, Joshua P. ; Nash, Mark S. / Vagus Nerve Stimulation in Rodent Models : An Overview of Technical Considerations. In: Frontiers in Neuroscience. 2019 ; Vol. 13.
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