Vaginal self-sampling for human papillomavirus infection as a primary cervical cancer screening tool in a haitian population

Joel C. Boggan, David K. Walmer, Gregory Henderson, Nahida Chakhtoura, Schatzi H. McCarthy, Harry J. Beauvais, Jennifer S. Smith

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Human papillomavirus (HPV) testing as primary cervical cancer screening has not been studied in Caribbean women.We tested vaginal self-collection versus physician cervical sampling in a population of Haitian women. Methods: Participants were screened for high-risk HPV with self-performed vaginal and clinician-collected cervical samples using Hybrid Capture 2 assays (Qiagen, Gaithersburg, MD). Women positive by either method then underwent colposcopy with biopsy of all visible lesions. Sensitivity and positive predictive value were calculated for each sample method compared with biopsy results, with k statistics performed for agreement. McNemar tests were performed for differences in sensitivity at >cervical intraepithelial neoplasia (CIN)-I and >CIN-II. Results: Of 1845 women screened, 446 (24.3%) were HPV positive by either method, including 105 (5.7%) only by vaginal swab and 53 (2.9%) only by cervical swab. Vaginal and cervical samples were 91.4% concordant (k = 0.73 [95% confidence interval, 0.69-0.77], P < 0.001). Overall, 133 HPV-positive women (29.9%) had CIN-I, whereas 32 (7.2%) had ≥CIN-II. The sensitivity of vaginal swabs was similar to cervical swabs for detecting ≥CIN-I (89.1% vs. 87.9%, respectively; P = 0.75) lesions and ≥CIN-II disease (87.5% vs. 96.9%, P = 0.18). Eighteen of 19 cases of CIN-III and invasive cancer were found by both methods. Conclusions: Human papillomavirus screening via self-collected vaginal swabs or physician-collected cervical swabs are feasible options in this Haitian population. The agreement between cervical and vaginal samples was high, suggesting that vaginal samplëConly algorithms for screening could be effective for improving screening rates in this underscreened population.

Original languageEnglish (US)
Pages (from-to)655-659
Number of pages5
JournalSexually Transmitted Diseases
Volume42
Issue number11
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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    Boggan, J. C., Walmer, D. K., Henderson, G., Chakhtoura, N., McCarthy, S. H., Beauvais, H. J., & Smith, J. S. (2015). Vaginal self-sampling for human papillomavirus infection as a primary cervical cancer screening tool in a haitian population. Sexually Transmitted Diseases, 42(11), 655-659. https://doi.org/10.1097/OLQ.0000000000000345