Vagal tone as a resilience factor in children with prenatal cocaine exposure

Stephen J. Sheinkopf, Linda L. Lagasse, Barry M. Lester, Jing Liu, Ronald Seifer, Charles R Bauer, Seetha Shankaran, Henrietta Bada, Abhik Das

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Abstract

Studies have investigated the potential effects of prenatal cocaine exposure (CE) on children's development. However, few studies have examined predictors of resilient outcomes in this population. We examined vagal tone (VT) as a resilience factor in prenatal CE. Utilizing data from the Maternal Lifestyle Study, a cumulative risk index was derived for children with and without prenatal CE. Presence of CE and other prenatal drugs was summed with postnatal risks in infancy to yield a 15-item risk index. Preschool cognitive outcomes, problem behaviors, and adaptive behaviors were measured. VT was assessed during an infant exam at 1 month and toy exploration at 36 months. We included children with complete physiologic data (217 CE, 333 non-CE). Children were classified as having consistently high, consistently low, or fluctuating VT at 1 and 36 months. Children were also classified as high versus low risk. High-risk children had lower IQ scores, more problem behaviors, and lower ratings of adaptive behaviors than low-risk children. A significant risk by VT-stability interaction indicated that for high-risk children, those with stable low VT had higher ratings of adaptive behaviors at 36 months. This is consistent with theory linking reduced VT during tasks to adaptive regulation and indicates that such regulatory functioning may serve as a protective factor in prenatal CE.

Original languageEnglish
Pages (from-to)649-673
Number of pages25
JournalDevelopment and Psychopathology
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2007

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Cocaine
Psychological Adaptation
Play and Playthings
Child Development
Life Style
Mothers
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Sheinkopf, S. J., Lagasse, L. L., Lester, B. M., Liu, J., Seifer, R., Bauer, C. R., ... Das, A. (2007). Vagal tone as a resilience factor in children with prenatal cocaine exposure. Development and Psychopathology, 19(3), 649-673. https://doi.org/10.1017/S0954579407000338

Vagal tone as a resilience factor in children with prenatal cocaine exposure. / Sheinkopf, Stephen J.; Lagasse, Linda L.; Lester, Barry M.; Liu, Jing; Seifer, Ronald; Bauer, Charles R; Shankaran, Seetha; Bada, Henrietta; Das, Abhik.

In: Development and Psychopathology, Vol. 19, No. 3, 01.06.2007, p. 649-673.

Research output: Contribution to journalArticle

Sheinkopf, SJ, Lagasse, LL, Lester, BM, Liu, J, Seifer, R, Bauer, CR, Shankaran, S, Bada, H & Das, A 2007, 'Vagal tone as a resilience factor in children with prenatal cocaine exposure', Development and Psychopathology, vol. 19, no. 3, pp. 649-673. https://doi.org/10.1017/S0954579407000338
Sheinkopf SJ, Lagasse LL, Lester BM, Liu J, Seifer R, Bauer CR et al. Vagal tone as a resilience factor in children with prenatal cocaine exposure. Development and Psychopathology. 2007 Jun 1;19(3):649-673. https://doi.org/10.1017/S0954579407000338
Sheinkopf, Stephen J. ; Lagasse, Linda L. ; Lester, Barry M. ; Liu, Jing ; Seifer, Ronald ; Bauer, Charles R ; Shankaran, Seetha ; Bada, Henrietta ; Das, Abhik. / Vagal tone as a resilience factor in children with prenatal cocaine exposure. In: Development and Psychopathology. 2007 ; Vol. 19, No. 3. pp. 649-673.
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