Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus

C. G. Murphy, W. T. Lucas, R. E. Means, S. Czajak, C. L. Hale, J. D. Lifson, A. Kaur, R. P. Johnson, D. M. Knipe, Ronald Charles Desrosiers

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

An effective vaccine for AIDS may require development of novel vectors capable of eliciting long-lasting immune responses. Here we report the development and use of replication-competent and replication-defective strains of recombinant herpes simplex virus (HSV) that express envelope and Nef antigens of simian immunodeficiency virus (SIV). The HSV recombinants induced antienvelope antibody responses that persisted at relatively stable levels for months after the last administration. Two of seven rhesus monkeys vaccinated with recombinant HSV were solidly protected, and another showed a sustained reduction in viral load following rectal challenge with pathogenic SIVmac239 at 22 weeks following the last vaccine administration. HSV vectors thus show great promise for being able to elicit persistent immune responses and to provide durable protection against AIDS.

Original languageEnglish (US)
Pages (from-to)7745-7754
Number of pages10
JournalJournal of Virology
Volume74
Issue number17
DOIs
StatePublished - 2000
Externally publishedYes

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Simian immunodeficiency virus
herpes simplex
Simian Immunodeficiency Virus
Simplexvirus
Vaccines
vaccines
viruses
immune response
AIDS Vaccines
viral load
Macaca mulatta
Viral Load
Antibody Formation
Acquired Immunodeficiency Syndrome
antigens
Antigens
antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus. / Murphy, C. G.; Lucas, W. T.; Means, R. E.; Czajak, S.; Hale, C. L.; Lifson, J. D.; Kaur, A.; Johnson, R. P.; Knipe, D. M.; Desrosiers, Ronald Charles.

In: Journal of Virology, Vol. 74, No. 17, 2000, p. 7745-7754.

Research output: Contribution to journalArticle

Murphy, CG, Lucas, WT, Means, RE, Czajak, S, Hale, CL, Lifson, JD, Kaur, A, Johnson, RP, Knipe, DM & Desrosiers, RC 2000, 'Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus', Journal of Virology, vol. 74, no. 17, pp. 7745-7754. https://doi.org/10.1128/JVI.74.17.7745-7754.2000
Murphy, C. G. ; Lucas, W. T. ; Means, R. E. ; Czajak, S. ; Hale, C. L. ; Lifson, J. D. ; Kaur, A. ; Johnson, R. P. ; Knipe, D. M. ; Desrosiers, Ronald Charles. / Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus. In: Journal of Virology. 2000 ; Vol. 74, No. 17. pp. 7745-7754.
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AU - Lucas, W. T.

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AU - Hale, C. L.

AU - Lifson, J. D.

AU - Kaur, A.

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AU - Desrosiers, Ronald Charles

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