Vaccine-induced CD8+ T cells control AIDS virus replication

Philip A. Mudd, Mauricio Martins, Adam J. Ericsen, Damien C. Tully, Karen A. Power, Alex T. Bean, Shari M. Piaskowski, Lijie Duan, Aaron Seese, Adrianne D. Gladden, Kim L. Weisgrau, Jessica R. Furlott, Young Il Kim, Marlon G Veloso De Santana, Eva Rakasz, Saverio Capuano Iii, Nancy A. Wilson, Myrna C. Bonaldo, Ricardo Galler, David B. AllisonMichael Piatak, Ashley T. Haase, Jeffrey D. Lifson, Todd M. Allen, David Watkins

Research output: Contribution to journalArticle

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Abstract

Developing a vaccine for human immunodeficiency virus (HIV) may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B*57 or HLA-B*27 (ref. 3). These alleles remain by far the most robust associations with low concentrations of plasma virus, yet the mechanism of control in these individuals is not entirely clear. Here we vaccinate Indian rhesus macaques that express Mamu-B*08, an animal model for HLA-B*27-mediated elite control, with three Mamu-B*08-restricted CD8+ T-cell epitopes, and demonstrate that these vaccinated animals control replication of the highly pathogenic clonal simian immunodeficiency virus (SIV) mac239 virus. High frequencies of CD8+ T cells against these Vif and Nef epitopes in the blood, lymph nodes and colon were associated with viral control. Moreover, the frequency of the CD8+ T-cell response against the Nef RL10 epitope (Nef amino acids 137-146) correlated significantly with reduced acute phase viraemia. Finally, two of the eight vaccinees lost control of viral replication in the chronic phase, concomitant with escape in all three targeted epitopes, further implicating these three CD8+ T-cell responses in the control of viral replication. Our findings indicate that narrowly targeted vaccine-induced virus-specific CD8+ T-cell responses can control replication of the AIDS virus.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalNature
Volume491
Issue number7422
DOIs
StatePublished - Nov 1 2012

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Virus Replication
Vaccines
HIV
T-Lymphocytes
Epitopes
HLA-B Antigens
Viruses
Alleles
Simian Immunodeficiency Virus
Histocompatibility
T-Lymphocyte Epitopes
Viremia
Macaca mulatta
Colon
Animal Models
Lymph Nodes
Amino Acids

ASJC Scopus subject areas

  • General

Cite this

Mudd, P. A., Martins, M., Ericsen, A. J., Tully, D. C., Power, K. A., Bean, A. T., ... Watkins, D. (2012). Vaccine-induced CD8+ T cells control AIDS virus replication. Nature, 491(7422), 129-133. https://doi.org/10.1038/nature11443

Vaccine-induced CD8+ T cells control AIDS virus replication. / Mudd, Philip A.; Martins, Mauricio; Ericsen, Adam J.; Tully, Damien C.; Power, Karen A.; Bean, Alex T.; Piaskowski, Shari M.; Duan, Lijie; Seese, Aaron; Gladden, Adrianne D.; Weisgrau, Kim L.; Furlott, Jessica R.; Kim, Young Il; De Santana, Marlon G Veloso; Rakasz, Eva; Iii, Saverio Capuano; Wilson, Nancy A.; Bonaldo, Myrna C.; Galler, Ricardo; Allison, David B.; Piatak, Michael; Haase, Ashley T.; Lifson, Jeffrey D.; Allen, Todd M.; Watkins, David.

In: Nature, Vol. 491, No. 7422, 01.11.2012, p. 129-133.

Research output: Contribution to journalArticle

Mudd, PA, Martins, M, Ericsen, AJ, Tully, DC, Power, KA, Bean, AT, Piaskowski, SM, Duan, L, Seese, A, Gladden, AD, Weisgrau, KL, Furlott, JR, Kim, YI, De Santana, MGV, Rakasz, E, Iii, SC, Wilson, NA, Bonaldo, MC, Galler, R, Allison, DB, Piatak, M, Haase, AT, Lifson, JD, Allen, TM & Watkins, D 2012, 'Vaccine-induced CD8+ T cells control AIDS virus replication', Nature, vol. 491, no. 7422, pp. 129-133. https://doi.org/10.1038/nature11443
Mudd PA, Martins M, Ericsen AJ, Tully DC, Power KA, Bean AT et al. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature. 2012 Nov 1;491(7422):129-133. https://doi.org/10.1038/nature11443
Mudd, Philip A. ; Martins, Mauricio ; Ericsen, Adam J. ; Tully, Damien C. ; Power, Karen A. ; Bean, Alex T. ; Piaskowski, Shari M. ; Duan, Lijie ; Seese, Aaron ; Gladden, Adrianne D. ; Weisgrau, Kim L. ; Furlott, Jessica R. ; Kim, Young Il ; De Santana, Marlon G Veloso ; Rakasz, Eva ; Iii, Saverio Capuano ; Wilson, Nancy A. ; Bonaldo, Myrna C. ; Galler, Ricardo ; Allison, David B. ; Piatak, Michael ; Haase, Ashley T. ; Lifson, Jeffrey D. ; Allen, Todd M. ; Watkins, David. / Vaccine-induced CD8+ T cells control AIDS virus replication. In: Nature. 2012 ; Vol. 491, No. 7422. pp. 129-133.
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