Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans Streptococci

T. Kitten, Cindy Munro, A. Wang, F. L. Macrina

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The FimA protein of Streptococcus parasanguis is a virulence factor in the rat model of endocarditis, and immunization with FimA protects rats against homologous bacterial challenge. Because FimA-like proteins are widespread among the oral streptococci, the leading cause of native valve endocarditis, we evaluated the ability of this vaccinogen to protect rats when challenged by other streptococcal species. Here we report that FimA vaccination produced antibodies that cross-reacted with and protected against challenge by the oral streptococci S. mitis, S. mutans, and S. salivarius. FimA thus has promise as a vaccinogen to control infective endocarditis caused by oral streptococci.

Original languageEnglish (US)
Pages (from-to)422-425
Number of pages4
JournalInfection and Immunity
Volume70
Issue number1
DOIs
StatePublished - Jan 12 2002
Externally publishedYes

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Viridans Streptococci
Endocarditis
Streptococcus
Vaccination
Streptococcus mitis
Virulence Factors
Immunization
Proteins
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans Streptococci. / Kitten, T.; Munro, Cindy; Wang, A.; Macrina, F. L.

In: Infection and Immunity, Vol. 70, No. 1, 12.01.2002, p. 422-425.

Research output: Contribution to journalArticle

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