Abstract
The FimA protein of Streptococcus parasanguis is a virulence factor in the rat model of endocarditis, and immunization with FimA protects rats against homologous bacterial challenge. Because FimA-like proteins are widespread among the oral streptococci, the leading cause of native valve endocarditis, we evaluated the ability of this vaccinogen to protect rats when challenged by other streptococcal species. Here we report that FimA vaccination produced antibodies that cross-reacted with and protected against challenge by the oral streptococci S. mitis, S. mutans, and S. salivarius. FimA thus has promise as a vaccinogen to control infective endocarditis caused by oral streptococci.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 422-425 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 70 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 12 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans Streptococci. / Kitten, T.; Munro, Cindy; Wang, A.; Macrina, F. L.
In: Infection and Immunity, Vol. 70, No. 1, 12.01.2002, p. 422-425.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans Streptococci
AU - Kitten, T.
AU - Munro, Cindy
AU - Wang, A.
AU - Macrina, F. L.
PY - 2002/1/12
Y1 - 2002/1/12
N2 - The FimA protein of Streptococcus parasanguis is a virulence factor in the rat model of endocarditis, and immunization with FimA protects rats against homologous bacterial challenge. Because FimA-like proteins are widespread among the oral streptococci, the leading cause of native valve endocarditis, we evaluated the ability of this vaccinogen to protect rats when challenged by other streptococcal species. Here we report that FimA vaccination produced antibodies that cross-reacted with and protected against challenge by the oral streptococci S. mitis, S. mutans, and S. salivarius. FimA thus has promise as a vaccinogen to control infective endocarditis caused by oral streptococci.
AB - The FimA protein of Streptococcus parasanguis is a virulence factor in the rat model of endocarditis, and immunization with FimA protects rats against homologous bacterial challenge. Because FimA-like proteins are widespread among the oral streptococci, the leading cause of native valve endocarditis, we evaluated the ability of this vaccinogen to protect rats when challenged by other streptococcal species. Here we report that FimA vaccination produced antibodies that cross-reacted with and protected against challenge by the oral streptococci S. mitis, S. mutans, and S. salivarius. FimA thus has promise as a vaccinogen to control infective endocarditis caused by oral streptococci.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036138304&partnerID=8YFLogxK
U2 - 10.1128/IAI.70.1.422-425.2002
DO - 10.1128/IAI.70.1.422-425.2002
M3 - Article
VL - 70
SP - 422
EP - 425
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -