Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans Streptococci

T. Kitten, C. L. Munro, A. Wang, F. L. Macrina

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The FimA protein of Streptococcus parasanguis is a virulence factor in the rat model of endocarditis, and immunization with FimA protects rats against homologous bacterial challenge. Because FimA-like proteins are widespread among the oral streptococci, the leading cause of native valve endocarditis, we evaluated the ability of this vaccinogen to protect rats when challenged by other streptococcal species. Here we report that FimA vaccination produced antibodies that cross-reacted with and protected against challenge by the oral streptococci S. mitis, S. mutans, and S. salivarius. FimA thus has promise as a vaccinogen to control infective endocarditis caused by oral streptococci.

Original languageEnglish (US)
Pages (from-to)422-425
Number of pages4
JournalInfection and immunity
Volume70
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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